Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing.

CD4(+) and CD8(+) T cell responses to endogenous retroviral envelope glycoprotein gp90 generate protective immunity to murine colon carcinoma CT26. A panel of I-A(d)-restricted T cell hybridomas recognize gp90 synthesized by CT26 cells but not by other gp90-expressing tumors. Here we report that ant...

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Hlavní autoři: Mimura, Y, Mimura-Kimura, Y, Doores, K, Golgher, D, Davis, B, Dwek, R, Rudd, P, Elliott, T
Médium: Journal article
Jazyk:English
Vydáno: 2007