Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants
<p style="text-align:justify;"> Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2009
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| _version_ | 1826306734639022080 |
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| author | Chau, TN Hieu, NT Anders, KL Wolbers, M Lien, LB Hieu, LT Hien, TT Hung, NT Farrar, J Whitehead, S Simmons, CP |
| author_facet | Chau, TN Hieu, NT Anders, KL Wolbers, M Lien, LB Hieu, LT Hien, TT Hung, NT Farrar, J Whitehead, S Simmons, CP |
| author_sort | Chau, TN |
| collection | OXFORD |
| description | <p style="text-align:justify;"> Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENV-reactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV-neutralizing and E protein–reactive IgG titers declined to below measurable levels in >90% of infants by 6 months of age. In contrast, IgG reactive with whole DENV virions persisted until 12 months of age in 20% of infants. Serological surveillance identified 10 infants with asymptomatic DENV infection for an incidence of 1.7 cases per 100 person-years. DENV-neutralizing antibodies remained measurable for ⩾1 year after infection. These results suggest that whereas DENV infection in infants is frequently subclinical, there is a window between 4 and 12 months of age where virion-binding but nonneutralizing IgG could facilitate antibody-dependent enhancement </p> |
| first_indexed | 2024-03-07T06:52:26Z |
| format | Journal article |
| id | oxford-uuid:fcfda7ea-cd30-43ea-b70b-d2bbacb97e8d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:52:26Z |
| publishDate | 2009 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:fcfda7ea-cd30-43ea-b70b-d2bbacb97e8d2022-03-27T13:25:29ZDengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infantsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fcfda7ea-cd30-43ea-b70b-d2bbacb97e8dEnglishSymplectic Elements at OxfordOxford University Press2009Chau, TNHieu, NTAnders, KLWolbers, MLien, LBHieu, LTHien, TTHung, NTFarrar, JWhitehead, SSimmons, CP <p style="text-align:justify;"> Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENV-reactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV-neutralizing and E protein–reactive IgG titers declined to below measurable levels in >90% of infants by 6 months of age. In contrast, IgG reactive with whole DENV virions persisted until 12 months of age in 20% of infants. Serological surveillance identified 10 infants with asymptomatic DENV infection for an incidence of 1.7 cases per 100 person-years. DENV-neutralizing antibodies remained measurable for ⩾1 year after infection. These results suggest that whereas DENV infection in infants is frequently subclinical, there is a window between 4 and 12 months of age where virion-binding but nonneutralizing IgG could facilitate antibody-dependent enhancement </p> |
| spellingShingle | Chau, TN Hieu, NT Anders, KL Wolbers, M Lien, LB Hieu, LT Hien, TT Hung, NT Farrar, J Whitehead, S Simmons, CP Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants |
| title | Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants |
| title_full | Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants |
| title_fullStr | Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants |
| title_full_unstemmed | Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants |
| title_short | Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants |
| title_sort | dengue virus infections and maternal antibody decay in a prospective birth cohort study of vietnamese infants |
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