Completeness of HIV-1 envelope glycan shield at transmission determines neutralization breadth
Densely arranged N-linked glycans shield the HIV-1 envelope (Env) trimer from antibody recognition. Strain-specific breaches in this shield (glycan holes) can be targets of vaccine-induced neutralizing antibodies that lack breadth. To understand the interplay between glycan holes and neutralization...
| Główni autorzy: | , , , , |
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| Format: | Journal article |
| Wydane: |
Cell Press
2018
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