Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis.

Melioidosis is caused by the soil saprophyte Burkholderia pseudomallei and is endemic in Southeast Asia. The pathogenesis of melioidosis is still largely unknown, although gamma interferon (IFN-gamma) seems to play an obligatory role in host defense. Previously, we have shown that IFN-gamma producti...

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Bibliographic Details
Main Authors: Wiersinga, W, Wieland, C, van der Windt, G, de Boer, A, Florquin, S, Dondorp, A, Day, N, Peacock, S, van der Poll, T
Format: Journal article
Language:English
Published: 2007