Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study.
INTRODUCTION: Ultra Short TE MRI allows signal to be detected from tissues with a very short T2.The aims of this study were to optimize a 2D UTE MRI sequence for imaging and quantification of sclerotic bone metastases, establish T2* values of sclerotic components and investigate the feasibility of...
| Автори: | , , , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
2010
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| _version_ | 1826306817545732096 |
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| author | Messiou, C Collins, D Morgan, V Robson, M deBono, J Bydder, G deSouza, N |
| author_facet | Messiou, C Collins, D Morgan, V Robson, M deBono, J Bydder, G deSouza, N |
| author_sort | Messiou, C |
| collection | OXFORD |
| description | INTRODUCTION: Ultra Short TE MRI allows signal to be detected from tissues with a very short T2.The aims of this study were to optimize a 2D UTE MRI sequence for imaging and quantification of sclerotic bone metastases, establish T2* values of sclerotic components and investigate the feasibility of using the method to assess changes in T2* of sclerotic metastases and their relation to attenuation values in patients on treatment. METHODS: Twenty-two subjects were recruited in 3 cohorts. Cohort 1 was used to optimize the 2-D UTE sequence, cohort 2 was used to establish T2* measurements using a range of TEs and cohort 3 was used to assess T2* changes with treatment response and relate them to changes on electron density as measured by CT Hounsfield Units. RESULTS: Sagittal 2D UTE MRI of the lumbar spine is feasible demonstrating short T2 components in normal volunteers. In patients with bone metastases secondary to prostate carcinoma T2* can be measured and mean T2* of sclerotic metastases measured with TEs of 0.07, 0.27, 0.47 and 0.67 ms was 8.5 ms.T2* shortened by 20.0% in responders and increased by 24.4% in progressors. DISCUSSION: The significant linear relationship between percentage change in T2* as derived from UTE MRI and percentage change in HU from corresponding CT studies is indirect evidence that they are measuring effects of the same process.If the relationship between T2* and electron density holds true in further studies it offers potential for MR guided radiotherapy planning as well as attenuation correction for PET/MRI. |
| first_indexed | 2024-03-07T06:53:39Z |
| format | Journal article |
| id | oxford-uuid:fd62d5f9-2eff-46f3-9bbf-07f65b6adef1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:53:39Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:fd62d5f9-2eff-46f3-9bbf-07f65b6adef12022-03-27T13:28:28ZQuantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fd62d5f9-2eff-46f3-9bbf-07f65b6adef1EnglishSymplectic Elements at Oxford2010Messiou, CCollins, DMorgan, VRobson, MdeBono, JBydder, GdeSouza, N INTRODUCTION: Ultra Short TE MRI allows signal to be detected from tissues with a very short T2.The aims of this study were to optimize a 2D UTE MRI sequence for imaging and quantification of sclerotic bone metastases, establish T2* values of sclerotic components and investigate the feasibility of using the method to assess changes in T2* of sclerotic metastases and their relation to attenuation values in patients on treatment. METHODS: Twenty-two subjects were recruited in 3 cohorts. Cohort 1 was used to optimize the 2-D UTE sequence, cohort 2 was used to establish T2* measurements using a range of TEs and cohort 3 was used to assess T2* changes with treatment response and relate them to changes on electron density as measured by CT Hounsfield Units. RESULTS: Sagittal 2D UTE MRI of the lumbar spine is feasible demonstrating short T2 components in normal volunteers. In patients with bone metastases secondary to prostate carcinoma T2* can be measured and mean T2* of sclerotic metastases measured with TEs of 0.07, 0.27, 0.47 and 0.67 ms was 8.5 ms.T2* shortened by 20.0% in responders and increased by 24.4% in progressors. DISCUSSION: The significant linear relationship between percentage change in T2* as derived from UTE MRI and percentage change in HU from corresponding CT studies is indirect evidence that they are measuring effects of the same process.If the relationship between T2* and electron density holds true in further studies it offers potential for MR guided radiotherapy planning as well as attenuation correction for PET/MRI. |
| spellingShingle | Messiou, C Collins, D Morgan, V Robson, M deBono, J Bydder, G deSouza, N Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study. |
| title | Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study. |
| title_full | Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study. |
| title_fullStr | Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study. |
| title_full_unstemmed | Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study. |
| title_short | Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study. |
| title_sort | quantifying sclerotic bone metastases with 2d ultra short te mri a feasibility study |
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