Xist gene regulation at the onset of X inactivation.
The large non-coding RNA Xist is the master regulator of X inactivation. Xist is negatively regulated by its antisense transcript Tsix. This repressive antisense transcription across Xist operates at least in part through the modification of the chromatin environment of the locus. However Tsix is no...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1826306820532076544 |
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| author | Senner, C Brockdorff, N |
| author_facet | Senner, C Brockdorff, N |
| author_sort | Senner, C |
| collection | OXFORD |
| description | The large non-coding RNA Xist is the master regulator of X inactivation. Xist is negatively regulated by its antisense transcript Tsix. This repressive antisense transcription across Xist operates at least in part through the modification of the chromatin environment of the locus. However Tsix is not sufficient to repress Xist in pluripotent cells and there is emerging evidence that transcription factors associated with pluripotency are involved in Tsix-independent repression. This review focuses on recent advances in this area and discusses the implications for our understanding of Xist gene regulation at the onset of X inactivation. |
| first_indexed | 2024-03-07T06:53:41Z |
| format | Journal article |
| id | oxford-uuid:fd66707c-9e2e-4f2f-b1c2-76b3a3865bf5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:53:41Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:fd66707c-9e2e-4f2f-b1c2-76b3a3865bf52022-03-27T13:28:31ZXist gene regulation at the onset of X inactivation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fd66707c-9e2e-4f2f-b1c2-76b3a3865bf5EnglishSymplectic Elements at Oxford2009Senner, CBrockdorff, NThe large non-coding RNA Xist is the master regulator of X inactivation. Xist is negatively regulated by its antisense transcript Tsix. This repressive antisense transcription across Xist operates at least in part through the modification of the chromatin environment of the locus. However Tsix is not sufficient to repress Xist in pluripotent cells and there is emerging evidence that transcription factors associated with pluripotency are involved in Tsix-independent repression. This review focuses on recent advances in this area and discusses the implications for our understanding of Xist gene regulation at the onset of X inactivation. |
| spellingShingle | Senner, C Brockdorff, N Xist gene regulation at the onset of X inactivation. |
| title | Xist gene regulation at the onset of X inactivation. |
| title_full | Xist gene regulation at the onset of X inactivation. |
| title_fullStr | Xist gene regulation at the onset of X inactivation. |
| title_full_unstemmed | Xist gene regulation at the onset of X inactivation. |
| title_short | Xist gene regulation at the onset of X inactivation. |
| title_sort | xist gene regulation at the onset of x inactivation |
| work_keys_str_mv | AT sennerc xistgeneregulationattheonsetofxinactivation AT brockdorffn xistgeneregulationattheonsetofxinactivation |