Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

Radiotherapy is a major treatment modality used to treat muscle-invasive bladder cancer, with patient outcomes similar to surgery. However, radioresistance is a significant factor in treatment failure. Cell-free extracts of muscle-invasive bladder tumors are defective in nonhomologous end-joining (N...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Qiao, B, Kerr, M, Groselj, B, Teo, M, Knowles, M, Bristow, R, Phillips, R, Kiltie, A
Format:	Journal article
Język:	English
Wydane:	2013

Podobne zapisy

Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity.
od: Choudhury, A, i wsp.
Wydane: (2009)

E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer
od: Nicholson, J, i wsp.
Wydane: (2017)

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
od: Nina M. S. Gustafsson, i wsp.
Wydane: (2018-09-01)

Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression
od: Groselj, B, i wsp.
Wydane: (2013)

Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression.
od: Groselj, B, i wsp.
Wydane: (2013)

The HDAC Inhibitor Panobinostat Promotes Expression of Delta 133p53 Variants in TP53 Wild-type Bladder Cancer Cells
od: Groselj, B, i wsp.
Wydane: (2012)

A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity
od: Benjamin C. Chandler, i wsp.
Wydane: (2020-05-01)

Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51.
od: Qiao Liu, i wsp.
Wydane: (2011-01-01)

RAD51: A DNA repair target for increasing the therapeutic potential in bladder cancer
od: Choudhury, A, i wsp.
Wydane: (2005)

Gemcitabine as a Chemoradiosensitiser in Bladder Cancer
od: Kerr, M, i wsp.
Wydane: (2012)

In vitro effects of imatinib mesylate on radiosensitivity and chemosensitivity of breast cancer cells
od: Weigel Marion T, i wsp.
Wydane: (2010-08-01)

Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination
od: Xin Zhang, i wsp.
Wydane: (2017-09-01)

Predictive Biomarkers for Gemcitabine as a Chemoradiosensitizer in Bladder Cancer
od: Kerr, M, i wsp.
Wydane: (2012)

Three-in-One Nanozyme for Radiosensitization of Bladder Cancer
od: Li Y, i wsp.
Wydane: (2024-10-01)

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
od: Chitnis, M, i wsp.
Wydane: (2014)

Radiosensitation in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity
od: Groselj, B, i wsp.
Wydane: (2017)

Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency
od: Tim Heemskerk, i wsp.
Wydane: (2025-03-01)

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
od: Manish Kumar, i wsp.
Wydane: (2021-11-01)

Selective targeting of homologous recombination deficiency
od: Zimmer, J
Wydane: (2014)

The HSP90 inhibitor NVP-AUY922 radiosensitizes by abrogation of homologous recombination resulting in mitotic entry with unresolved DNA damage.
od: Shane Zaidi, i wsp.
Wydane: (2012-01-01)

Analysis of variants in DNA damage signalling genes in bladder cancer
od: Choudhury, A, i wsp.
Wydane: (2008)

Targeting homologous recombination deficiency in uterine leiomyosarcoma
od: Genevieve Dall, i wsp.
Wydane: (2023-05-01)

N6-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression
od: Giovanna Navarra, i wsp.
Wydane: (2020-01-01)

Regulators of Homologous Recombination Repair as Novel Targets for Cancer Treatment
od: Małgorzata ekrajewska, i wsp.
Wydane: (2015-03-01)

Targeting acid ceramidase to improve the radiosensitivity of rectal cancer
od: Clifford, R, i wsp.
Wydane: (2020)

Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts.
od: Diggle, C, i wsp.
Wydane: (2005)

In vitro functional effects of XPC gene rare variants from bladder cancer patients.
od: Qiao, B, i wsp.
Wydane: (2011)

MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.
od: Choudhury, A, i wsp.
Wydane: (2010)

Assessment of acute bowel toxicity from chemoradiation for bladder cancer using an in vivo gastrointestinal crypt assay and in vitro organoid system
od: Gorrill, J, i wsp.
Wydane: (2017)

P53 gene targeting by homologous recombination in fish ES cells
od: Yan, Yan, i wsp.
Wydane: (2013)

p53 gene targeting by homologous recombination in fish ES cells.
od: Yan Yan, i wsp.
Wydane: (2013-01-01)

Histone deacetylase inhibitors as radiosensitisers: Effects on DNA damage signalling and repair
od: Groselj, B, i wsp.
Wydane: (2013)

Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair.
od: Groselj, B, i wsp.
Wydane: (2013)

Targeting the organelle for radiosensitization in cancer radiotherapy
od: Xiaoyan Sun, i wsp.
Wydane: (2024-04-01)

Radiosensitization in prostate cancer: mechanisms and targets
od: Palacios Diego A, i wsp.
Wydane: (2013-01-01)

Fibroblast radiosensitivity measured using the comet assay correlates with clonogenic survival parameters
od: Eastham, A, i wsp.
Wydane: (1999)

BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibiting homologous recombination repair
od: Yangyang Kong, i wsp.
Wydane: (2022-08-01)

Pan-cancer landscape of homologous recombination deficiency
od: Luan Nguyen, i wsp.
Wydane: (2020-11-01)

The histone deacetylase inhibitor panobinostat as a radiosensitiser in bladder cancer
od: Groselj, B
Wydane: (2014)

Homologous Recombination Assay
od: Yvan Canitrot, i wsp.
Wydane: (2013-09-01)