Glucosylceramide modulates membrane traffic along the endocytic pathway.

Glucosylceramide modulates membrane traffic along the endocytic pathway.

Glycosphingolipids are endocytosed and targeted to the Golgi apparatus, but are mistargeted to lysosomes in numerous sphingolipidoses. Substrate reduction therapy utilizes imino sugars to inhibit glucosylceramide synthase and potentially abrogate the effects of storage. Gaucher disease is a heredita...

Полное описание

Библиографические подробности
Главные авторы:	Sillence, D, Puri, V, Marks, D, Butters, T, Dwek, R, Pagano, R, Platt, F
Формат:	Journal article
Язык:	English
Опубликовано:	2002

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