Glucosylceramide modulates membrane traffic along the endocytic pathway.

Glycosphingolipids are endocytosed and targeted to the Golgi apparatus, but are mistargeted to lysosomes in numerous sphingolipidoses. Substrate reduction therapy utilizes imino sugars to inhibit glucosylceramide synthase and potentially abrogate the effects of storage. Gaucher disease is a heredita...

詳細記述

書誌詳細
主要な著者: Sillence, D, Puri, V, Marks, D, Butters, T, Dwek, R, Pagano, R, Platt, F
フォーマット: Journal article
言語:English
出版事項: 2002