Intracellular Ca2+ release and synaptic plasticity: A tale of many stores
Ca2+ is an essential trigger for most forms of synaptic plasticity. Ca2+ signaling occurs not only by Ca2+ entry via plasma membrane channels but also via Ca2+ signals generated by intracellular organelles. These organelles, by dynamically regulating the spatial and temporal extent of Ca2+ elevation...
| Main Authors: | , , |
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| Format: | Journal article |
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SAGE Publications
2018
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| _version_ | 1826306853864210432 |
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| author | Padamsey, Z Foster, W Emptage, NJ |
| author_facet | Padamsey, Z Foster, W Emptage, NJ |
| author_sort | Padamsey, Z |
| collection | OXFORD |
| description | Ca2+ is an essential trigger for most forms of synaptic plasticity. Ca2+ signaling occurs not only by Ca2+ entry via plasma membrane channels but also via Ca2+ signals generated by intracellular organelles. These organelles, by dynamically regulating the spatial and temporal extent of Ca2+ elevations within neurons, play a pivotal role in determining the downstream consequences of neural signaling on synaptic function. Here, we review the role of three major intracellular stores: the endoplasmic reticulum, mitochondria, and acidic Ca2+ stores, such as lysosomes, in neuronal Ca2+ signaling and plasticity. We provide a comprehensive account of how Ca2+ release from these stores regulates short- and long-term plasticity at the pre- and postsynaptic terminals of central synapses. |
| first_indexed | 2024-03-07T06:54:11Z |
| format | Journal article |
| id | oxford-uuid:fd90d492-e215-4dc9-91d5-8ba51f481add |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:54:11Z |
| publishDate | 2018 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:fd90d492-e215-4dc9-91d5-8ba51f481add2022-03-27T13:29:44ZIntracellular Ca2+ release and synaptic plasticity: A tale of many storesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fd90d492-e215-4dc9-91d5-8ba51f481addSymplectic Elements at OxfordSAGE Publications2018Padamsey, ZFoster, WEmptage, NJCa2+ is an essential trigger for most forms of synaptic plasticity. Ca2+ signaling occurs not only by Ca2+ entry via plasma membrane channels but also via Ca2+ signals generated by intracellular organelles. These organelles, by dynamically regulating the spatial and temporal extent of Ca2+ elevations within neurons, play a pivotal role in determining the downstream consequences of neural signaling on synaptic function. Here, we review the role of three major intracellular stores: the endoplasmic reticulum, mitochondria, and acidic Ca2+ stores, such as lysosomes, in neuronal Ca2+ signaling and plasticity. We provide a comprehensive account of how Ca2+ release from these stores regulates short- and long-term plasticity at the pre- and postsynaptic terminals of central synapses. |
| spellingShingle | Padamsey, Z Foster, W Emptage, NJ Intracellular Ca2+ release and synaptic plasticity: A tale of many stores |
| title | Intracellular Ca2+ release and synaptic plasticity: A tale of many stores |
| title_full | Intracellular Ca2+ release and synaptic plasticity: A tale of many stores |
| title_fullStr | Intracellular Ca2+ release and synaptic plasticity: A tale of many stores |
| title_full_unstemmed | Intracellular Ca2+ release and synaptic plasticity: A tale of many stores |
| title_short | Intracellular Ca2+ release and synaptic plasticity: A tale of many stores |
| title_sort | intracellular ca2 release and synaptic plasticity a tale of many stores |
| work_keys_str_mv | AT padamseyz intracellularca2releaseandsynapticplasticityataleofmanystores AT fosterw intracellularca2releaseandsynapticplasticityataleofmanystores AT emptagenj intracellularca2releaseandsynapticplasticityataleofmanystores |