Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.

The broad substrate specificity of herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) has provided the basis for selective antiherpetic therapy and, more recently, suicide gene therapy for the treatment of cancer. We have now constructed an HSV-1 TK mutant enzyme, in which an asparagine (N) r...

Popoln opis

Bibliografske podrobnosti
Main Authors: Degrève, B, Esnouf, R, De Clercq, E, Balzarini, J
Format: Journal article
Jezik:English
Izdano: 2001