Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network
Objectives To monitor changes in seroprevalence of SARS-CoV-2 antibodies in populations over time and between different demographic groups. Methods A subset of practices in the Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) sentinel network provided serum...
| मुख्य लेखकों: | , , , , , , , , , , , , , , , , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Elsevier
2022
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| _version_ | 1826307911058456576 |
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| author | Whitaker, H Tsang, RS Button, E Andrews, N Byford, R Borrow, R Hobbs, FR Brooks, T Howsam, G Brown, K Macartney, J Gower, C Okusi, C Hewson, J Sherlock, J Linley, E Tripathy, M Otter, AD Williams, J Tonge, S Lusignan, SD Amirthalingam, G |
| author_facet | Whitaker, H Tsang, RS Button, E Andrews, N Byford, R Borrow, R Hobbs, FR Brooks, T Howsam, G Brown, K Macartney, J Gower, C Okusi, C Hewson, J Sherlock, J Linley, E Tripathy, M Otter, AD Williams, J Tonge, S Lusignan, SD Amirthalingam, G |
| author_sort | Whitaker, H |
| collection | OXFORD |
| description | Objectives
To monitor changes in seroprevalence of SARS-CoV-2 antibodies in populations over time and between different demographic groups.
Methods
A subset of practices in the Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) sentinel network provided serum samples, collected when volunteer patients had routine blood tests. We tested these samples for SARS-CoV-2 antibodies using Abbott (Chicago, USA), Roche (Basel, Switzerland) and/or Euroimmun (Luebeck, Germany) assays, and linked the results to the patients’ primary care computerised medical records.
We report seropositivity by region and age group, and additionally examined the effects of gender, ethnicity, deprivation, rurality, shielding recommendation and smoking status.
Results
We estimated seropositivity from patients aged 18-100 years old, which ranged from 4.1% (95% CI 3.1–5.3%) to 8.9% (95% CI 7.8–10.2%) across the different assays and time periods. We found higher Euroimmun seropositivity in younger age groups, people of Black and Asian ethnicity (compared to white), major conurbations, and non-smokers. We did not observe any significant effect by region, gender, deprivation, or shielding recommendation.
Conclusions
Our results suggest that prior to the vaccination programme, most of the population remained unexposed to SARS-CoV-2.
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| first_indexed | 2024-03-07T07:11:38Z |
| format | Journal article |
| id | oxford-uuid:fdaa7b39-a4cd-4bb2-b51e-2c2ff4942ea3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:11:38Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:fdaa7b39-a4cd-4bb2-b51e-2c2ff4942ea32022-06-15T13:26:51ZSociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel networkJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fdaa7b39-a4cd-4bb2-b51e-2c2ff4942ea3EnglishSymplectic ElementsElsevier2022Whitaker, HTsang, RSButton, EAndrews, NByford, RBorrow, RHobbs, FRBrooks, THowsam, GBrown, KMacartney, JGower, COkusi, CHewson, JSherlock, JLinley, ETripathy, MOtter, ADWilliams, JTonge, SLusignan, SDAmirthalingam, GObjectives To monitor changes in seroprevalence of SARS-CoV-2 antibodies in populations over time and between different demographic groups. Methods A subset of practices in the Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) sentinel network provided serum samples, collected when volunteer patients had routine blood tests. We tested these samples for SARS-CoV-2 antibodies using Abbott (Chicago, USA), Roche (Basel, Switzerland) and/or Euroimmun (Luebeck, Germany) assays, and linked the results to the patients’ primary care computerised medical records. We report seropositivity by region and age group, and additionally examined the effects of gender, ethnicity, deprivation, rurality, shielding recommendation and smoking status. Results We estimated seropositivity from patients aged 18-100 years old, which ranged from 4.1% (95% CI 3.1–5.3%) to 8.9% (95% CI 7.8–10.2%) across the different assays and time periods. We found higher Euroimmun seropositivity in younger age groups, people of Black and Asian ethnicity (compared to white), major conurbations, and non-smokers. We did not observe any significant effect by region, gender, deprivation, or shielding recommendation. Conclusions Our results suggest that prior to the vaccination programme, most of the population remained unexposed to SARS-CoV-2. |
| spellingShingle | Whitaker, H Tsang, RS Button, E Andrews, N Byford, R Borrow, R Hobbs, FR Brooks, T Howsam, G Brown, K Macartney, J Gower, C Okusi, C Hewson, J Sherlock, J Linley, E Tripathy, M Otter, AD Williams, J Tonge, S Lusignan, SD Amirthalingam, G Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network |
| title | Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network |
| title_full | Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network |
| title_fullStr | Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network |
| title_full_unstemmed | Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network |
| title_short | Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network |
| title_sort | sociodemographic disparities in covid 19 seroprevalence across england in the oxford rcgp primary care sentinel network |
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