UHRF1 Is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi Anemia pathway
The Fanconi anemia (FA) pathway is critical for the cellular response to toxic DNA interstrand crosslinks (ICLs). Using a biochemical purification strategy, we identified UHRF1 as a protein that specifically interacts with ICLs invitro and invivo. Reduction of cellular levels of UHRF1 by RNAi attenu...
Main Authors: | Liang, C, Zhan, B, Yoshikawa, Y, Haas, W, Gygi, S, Cohn, M |
---|---|
Format: | Journal article |
Published: |
Cell Press
2015
|
Similar Items
-
UHRF1 Is a Sensor for DNA Interstrand Crosslinks and Recruits FANCD2 to Initiate the Fanconi Anemia Pathway
by: Chih-Chao Liang, et al.
Published: (2015-03-01) -
Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein
by: Motnenko, A, et al.
Published: (2018) -
UHRF1 is a sensor for DNA interstrand crosslinks.
by: Cohn, M, et al.
Published: (2016) -
Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.
by: Anna Motnenko, et al.
Published: (2018-10-01) -
The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks prior to monoubiquitination of FANCD2
by: Liang, C, et al.
Published: (2016)