Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk.
Myocardial infarction (MI) remains the most common cause of heart failure (HF) worldwide. For almost 50 years HF has been recognised as a determinant of adverse prognosis after MI, but efforts to promote myocardial repair have failed to translate into clinical therapies. Primary percutaneous coronar...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Baishideng Publishing Group
2017
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| _version_ | 1826306893583220736 |
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| author | Cahill, T Kharbanda, R |
| author_facet | Cahill, T Kharbanda, R |
| author_sort | Cahill, T |
| collection | OXFORD |
| description | Myocardial infarction (MI) remains the most common cause of heart failure (HF) worldwide. For almost 50 years HF has been recognised as a determinant of adverse prognosis after MI, but efforts to promote myocardial repair have failed to translate into clinical therapies. Primary percutaneous coronary intervention (PPCI) has driven improved early survival after MI, but its impact on the incidence of downstream HF is debated. The effects of PPCI are confounded by the changing epidemiology of MI and HF, with an ageing patient demographic, an increasing proportion of non-ST-elevation myocardial infarction, and the recognition of HF with preserved ejection fraction. Herein we review the mechanisms of HF after MI and discuss contemporary data on its incidence and outcomes. We review current and emerging strategies for early detection of patients at risk of HF after MI, with a view to identification of patient cohorts for novel therapeutic agents. |
| first_indexed | 2024-03-07T06:54:48Z |
| format | Journal article |
| id | oxford-uuid:fdc1d4cc-8be1-437d-89d1-21ac5ccbd7f6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:54:48Z |
| publishDate | 2017 |
| publisher | Baishideng Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:fdc1d4cc-8be1-437d-89d1-21ac5ccbd7f62022-03-27T13:31:18ZHeart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fdc1d4cc-8be1-437d-89d1-21ac5ccbd7f6EnglishSymplectic Elements at OxfordBaishideng Publishing Group2017Cahill, TKharbanda, RMyocardial infarction (MI) remains the most common cause of heart failure (HF) worldwide. For almost 50 years HF has been recognised as a determinant of adverse prognosis after MI, but efforts to promote myocardial repair have failed to translate into clinical therapies. Primary percutaneous coronary intervention (PPCI) has driven improved early survival after MI, but its impact on the incidence of downstream HF is debated. The effects of PPCI are confounded by the changing epidemiology of MI and HF, with an ageing patient demographic, an increasing proportion of non-ST-elevation myocardial infarction, and the recognition of HF with preserved ejection fraction. Herein we review the mechanisms of HF after MI and discuss contemporary data on its incidence and outcomes. We review current and emerging strategies for early detection of patients at risk of HF after MI, with a view to identification of patient cohorts for novel therapeutic agents. |
| spellingShingle | Cahill, T Kharbanda, R Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk. |
| title | Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk. |
| title_full | Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk. |
| title_fullStr | Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk. |
| title_full_unstemmed | Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk. |
| title_short | Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk. |
| title_sort | heart failure after myocardial infarction in the era of primary percutaneous coronary intervention mechanisms incidence and identification of patients at risk |
| work_keys_str_mv | AT cahillt heartfailureaftermyocardialinfarctionintheeraofprimarypercutaneouscoronaryinterventionmechanismsincidenceandidentificationofpatientsatrisk AT kharbandar heartfailureaftermyocardialinfarctionintheeraofprimarypercutaneouscoronaryinterventionmechanismsincidenceandidentificationofpatientsatrisk |