Heregulin-induced epigenetic regulation of the utrophin-A promoter.
Utrophin is the autosomal homolog of dystrophin, the product of the Duchenne's muscular dystrophy (DMD) locus. Utrophin is of therapeutic interest since its over-expression can compensate dystrophin's absence. Utrophin is enriched at neuromuscular junctions due to heregulin-mediated utroph...
| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
2007
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| _version_ | 1826306901184348160 |
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| author | Basu, U Gyrd-Hansen, M Baby, S Lozynska, O Krag, T Jensen, C Frödin, M Khurana, T |
| author_facet | Basu, U Gyrd-Hansen, M Baby, S Lozynska, O Krag, T Jensen, C Frödin, M Khurana, T |
| author_sort | Basu, U |
| collection | OXFORD |
| description | Utrophin is the autosomal homolog of dystrophin, the product of the Duchenne's muscular dystrophy (DMD) locus. Utrophin is of therapeutic interest since its over-expression can compensate dystrophin's absence. Utrophin is enriched at neuromuscular junctions due to heregulin-mediated utrophin-A promoter activation. We demonstrate that heregulin activated MSK1/2 and phosphorylated histone H3 at serine 10 in cultured C2C12 muscle cells, in an ERK-dependent manner. MSK1/2 inhibition suppressed heregulin-mediated utrophin-A activation. MSK1 over-expression potentiated heregulin-mediated utrophin-A activation and chromatin remodeling at the utrophin-A promoter. These results identify MSK1/2 as key effectors modulating utrophin-A expression as well as identify novel targets for DMD therapy. |
| first_indexed | 2024-03-07T06:54:55Z |
| format | Journal article |
| id | oxford-uuid:fdce1115-f765-4cbd-bbe5-09ccfda9eb8e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:54:55Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:fdce1115-f765-4cbd-bbe5-09ccfda9eb8e2022-03-27T13:31:36ZHeregulin-induced epigenetic regulation of the utrophin-A promoter.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fdce1115-f765-4cbd-bbe5-09ccfda9eb8eEnglishSymplectic Elements at Oxford2007Basu, UGyrd-Hansen, MBaby, SLozynska, OKrag, TJensen, CFrödin, MKhurana, TUtrophin is the autosomal homolog of dystrophin, the product of the Duchenne's muscular dystrophy (DMD) locus. Utrophin is of therapeutic interest since its over-expression can compensate dystrophin's absence. Utrophin is enriched at neuromuscular junctions due to heregulin-mediated utrophin-A promoter activation. We demonstrate that heregulin activated MSK1/2 and phosphorylated histone H3 at serine 10 in cultured C2C12 muscle cells, in an ERK-dependent manner. MSK1/2 inhibition suppressed heregulin-mediated utrophin-A activation. MSK1 over-expression potentiated heregulin-mediated utrophin-A activation and chromatin remodeling at the utrophin-A promoter. These results identify MSK1/2 as key effectors modulating utrophin-A expression as well as identify novel targets for DMD therapy. |
| spellingShingle | Basu, U Gyrd-Hansen, M Baby, S Lozynska, O Krag, T Jensen, C Frödin, M Khurana, T Heregulin-induced epigenetic regulation of the utrophin-A promoter. |
| title | Heregulin-induced epigenetic regulation of the utrophin-A promoter. |
| title_full | Heregulin-induced epigenetic regulation of the utrophin-A promoter. |
| title_fullStr | Heregulin-induced epigenetic regulation of the utrophin-A promoter. |
| title_full_unstemmed | Heregulin-induced epigenetic regulation of the utrophin-A promoter. |
| title_short | Heregulin-induced epigenetic regulation of the utrophin-A promoter. |
| title_sort | heregulin induced epigenetic regulation of the utrophin a promoter |
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