Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Εμφάνιση άλλων εκδόσεων (1)

Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detri...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Khurana, V, Elson-Schwab, I, Fulga, T, Sharp, K, Loewen, C, Mulkearns, E, Tyynelä, J, Scherzer, C, Feany, M
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2010

Παρόμοια τεκμήρια

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ανά: Steinhilb, M, κ.ά.
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ανά: Periquet, M, κ.ά.
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ανά: Dias-Santagata, D, κ.ά.
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ανά: Carli K. Opland, κ.ά.
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ανά: Khurana, V, κ.ά.
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ανά: Vanessa Plouffe, κ.ά.
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ανά: Emiko Miura, κ.ά.
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ανά: Ester Piovesana, κ.ά.
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ανά: Troy T. Rohn, κ.ά.
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ανά: Mario de la Mata, κ.ά.
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ανά: Platt, F, κ.ά.
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