Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detri...
मुख्य लेखकों: | Khurana, V, Elson-Schwab, I, Fulga, T, Sharp, K, Loewen, C, Mulkearns, E, Tyynelä, J, Scherzer, C, Feany, M |
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स्वरूप: | Journal article |
भाषा: | English |
प्रकाशित: |
2010
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समान संसाधन
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Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo
द्वारा: Khurana, V, और अन्य
प्रकाशित: (2010) -
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
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The unfolded protein response protects from tau neurotoxicity in vivo.
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Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.
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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
द्वारा: Fulga, T, और अन्य
प्रकाशित: (2007)