Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Бусад хувилбаруудыг харуулах (1)

Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detri...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Khurana, V, Elson-Schwab, I, Fulga, T, Sharp, K, Loewen, C, Mulkearns, E, Tyynelä, J, Scherzer, C, Feany, M
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2010

Ижил төстэй зүйлс

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo
-н: Khurana, V, зэрэг
Хэвлэсэн: (2010)

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
-н: Vikram Khurana, зэрэг
Хэвлэсэн: (2010-07-01)

The unfolded protein response protects from tau neurotoxicity in vivo.
-н: Carin A Loewen, зэрэг
Хэвлэсэн: (2010-09-01)

Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.
-н: Steinhilb, M, зэрэг
Хэвлэсэн: (2007)

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
-н: Fulga, T, зэрэг
Хэвлэсэн: (2007)

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.
-н: Periquet, M, зэрэг
Хэвлэсэн: (2007)

Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
-н: Dias-Santagata, D, зэрэг
Хэвлэсэн: (2007)

The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity
-н: Jiaqiao Lu, зэрэг
Хэвлэсэн: (2024-01-01)

Tau Oligomers Neurotoxicity
-н: Grazyna Niewiadomska, зэрэг
Хэвлэсэн: (2021-01-01)

Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity
-н: Carli K. Opland, зэрэг
Хэвлэсэн: (2023-06-01)

Senseless makes sense for spinocerebellar ataxia-1.
-н: Khurana, V, зэрэг
Хэвлэсэн: (2005)

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
-н: Xingyu Zhang, зэрэг
Хэвлэсэн: (2021-05-01)

Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
-н: Souvarish Sarkar, зэрэг
Хэвлэсэн: (2021-05-01)

Acrylamide‐induced autophagy‐lysosomal pathway dysfunction contributing to neurotoxicity through targeting transcription factor EB
-н: Liuqing Yang, зэрэг
Хэвлэсэн: (2023-09-01)

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans
-н: Caitlin S. Latimer, зэрэг
Хэвлэсэн: (2022-04-01)

Hyperphosphorylation and cleavage at D421 enhance tau secretion.
-н: Vanessa Plouffe, зэрэг
Хэвлэсэн: (2012-01-01)

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
-н: Emiko Miura, зэрэг
Хэвлэсэн: (2014-11-01)

Tau accumulation in degradative organelles is associated to lysosomal stress
-н: Ester Piovesana, зэрэг
Хэвлэсэн: (2023-10-01)

A neuroprotective role for the DNA damage checkpoint in tauopathy
-н: Khurana, V, зэрэг
Хэвлэсэн: (2012)

Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain
-н: Troy T. Rohn, зэрэг
Хэвлэсэн: (2002-11-01)

OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy
-н: Yin Xu, зэрэг
Хэвлэсэн: (2022-06-01)

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy
-н: Yingjian You, зэрэг
Хэвлэсэн: (2019-02-01)

A neuroprotective role for the DNA damage checkpoint in tauopathy.
-н: Khurana, V, зэрэг
Хэвлэсэн: (2012)

Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3
-н: Chul-Woong Chung, зэрэг
Хэвлэсэн: (2001-02-01)

Age-Related Lysosomal Dysfunctions
-н: Lena Guerrero-Navarro, зэрэг
Хэвлэсэн: (2022-06-01)

Lysosomal dysfunction in diabetic cardiomyopathy
-н: Satoru Kobayashi, зэрэг
Хэвлэсэн: (2023-01-01)

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.
-н: Meigen Yu, зэрэг
Хэвлэсэн: (2023-05-01)

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
-н: Bilal R. Malik, зэрэг
Хэвлэсэн: (2019-11-01)

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
-н: Vinicia A Polito, зэрэг
Хэвлэсэн: (2014-07-01)

Cleavage of Hsp70.1 causes lysosomal cell death under stress conditions
-н: Tetsumori Yamashima, зэрэг
Хэвлэсэн: (2024-05-01)

Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage
-н: Julie Pilliod, зэрэг
Хэвлэсэн: (2022-10-01)

Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease
-н: Seong Su Kang, зэрэг
Хэвлэсэн: (2020-08-01)

Lysosomal-endolysomal dysfunction and neurodegenerative diseases
-н: Matthew E. Gegg, зэрэг
Хэвлэсэн: (2022-10-01)

Mitochondrial Dysfunction in Lysosomal Storage Disorders
-н: Mario de la Mata, зэрэг
Хэвлэсэн: (2016-10-01)

The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction.
-н: Platt, F, зэрэг
Хэвлэсэн: (2012)

The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates
-н: Jiaxin Yang, зэрэг
Хэвлэсэн: (2023-03-01)

The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity
-н: Jingjing Zhang, зэрэг
Хэвлэсэн: (2023-01-01)

DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity
-н: Bangfu Zhu, зэрэг
Хэвлэсэн: (2022-09-01)

Self‐Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice
-н: Ly Thi Huong Luu Le, зэрэг
Хэвлэсэн: (2023-10-01)

Dual Vulnerability of Tau to Calpains and Caspase-3 Proteolysis Under Neurotoxic and Neurodegenerative Conditions
-н: Ming Cheng Liu, зэрэг
Хэвлэсэн: (2010-11-01)