Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

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Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detri...

Bibliografske podrobnosti
Main Authors:	Khurana, V, Elson-Schwab, I, Fulga, T, Sharp, K, Loewen, C, Mulkearns, E, Tyynelä, J, Scherzer, C, Feany, M
Format:	Journal article
Jezik:	English
Izdano:	2010

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