Dendritic integration of sensory evidence in perceptual decision-making
Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accu...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2018
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| _version_ | 1826311691797790720 |
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| author | Groschner, LN Hak, LCW Bogacz, R DasGupta, S Miesenböck, G |
| author_facet | Groschner, LN Hak, LCW Bogacz, R DasGupta, S Miesenböck, G |
| author_sort | Groschner, LN |
| collection | OXFORD |
| description | Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling. |
| first_indexed | 2024-03-07T08:13:29Z |
| format | Journal article |
| id | oxford-uuid:fde443dc-1c05-4506-9e71-576ebf772979 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:13:29Z |
| publishDate | 2018 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:fde443dc-1c05-4506-9e71-576ebf7729792023-12-05T16:34:57ZDendritic integration of sensory evidence in perceptual decision-makingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fde443dc-1c05-4506-9e71-576ebf772979EnglishSymplectic Elements at OxfordCell Press2018Groschner, LNHak, LCWBogacz, RDasGupta, SMiesenböck, GPerceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling. |
| spellingShingle | Groschner, LN Hak, LCW Bogacz, R DasGupta, S Miesenböck, G Dendritic integration of sensory evidence in perceptual decision-making |
| title | Dendritic integration of sensory evidence in perceptual decision-making |
| title_full | Dendritic integration of sensory evidence in perceptual decision-making |
| title_fullStr | Dendritic integration of sensory evidence in perceptual decision-making |
| title_full_unstemmed | Dendritic integration of sensory evidence in perceptual decision-making |
| title_short | Dendritic integration of sensory evidence in perceptual decision-making |
| title_sort | dendritic integration of sensory evidence in perceptual decision making |
| work_keys_str_mv | AT groschnerln dendriticintegrationofsensoryevidenceinperceptualdecisionmaking AT haklcw dendriticintegrationofsensoryevidenceinperceptualdecisionmaking AT bogaczr dendriticintegrationofsensoryevidenceinperceptualdecisionmaking AT dasguptas dendriticintegrationofsensoryevidenceinperceptualdecisionmaking AT miesenbockg dendriticintegrationofsensoryevidenceinperceptualdecisionmaking |