CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.
Base excision repair (BER) is the major pathway for processing of simple lesions in DNA, including single-strand breaks, base damage, and base loss. The scaffold protein XRCC1, DNA polymerase beta, and DNA ligase IIIalpha play pivotal roles in BER. Although all these enzymes are essential for develo...
Những tác giả chính: | Parsons, J, Tait, P, Finch, D, Dianova, I, Allinson, S, Dianov, G |
---|---|
Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
2008
|
Những quyển sách tương tự
-
DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.
Bằng: Parsons, J, et al.
Được phát hành: (2005) -
XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.
Bằng: Dianova, I, et al.
Được phát hành: (2004) -
XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair.
Bằng: Parsons, J, et al.
Được phát hành: (2010) -
Repair of abasic sites in DNA.
Bằng: Dianov, G, et al.
Được phát hành: (2003) -
Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts.
Bằng: Parsons, J, et al.
Được phát hành: (2005)