Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human peripheral blood mononuclear cells

A major challenge to TB vaccine development is the lack of a validated immune correlate of protection. Mycobacterial growth inhibition assays (MGIAs) represent an unbiased measure of the ability to control mycobacterial growth in vitro. A successful MGIA could be applied to preclinical and clinical...

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Bibliographic Details
Main Authors: Tanner, R, Smith, SG, Van Meijgaarden, KE, Giannoni, F, Wilkie, M, Gabriele, L, Palma, C, Dockrell, HM, Ottenhoff, THM, McShane, H
Format: Journal article
Language:English
Published: Elsevier 2019