Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.

Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.

Mutations in the glucokinase (GK) gene cause defects in blood glucose homeostasis. In some cases (V62M and G72R), the phenotype cannot be explained by altered enzyme kinetics or protein instability. We used transient and stable expression of green fluorescent protein (GFP) GK chimaeras in MIN6 beta-...

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Bibliographic Details
Main Authors:	Arden, C, Trainer, A, de la Iglesia, N, Scougall, K, Gloyn, A, Lange, A, Shaw, J, Matschinsky, F, Agius, L
Format:	Journal article
Language:	English
Published:	2007

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