Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy.
With increasing interest in treating osteoarthritis at its earliest stages, it has become important to understand the mechanisms by which the disease progresses across a joint. Here, second harmonic generation (SHG) microscopy, coupled with a two-dimensional spring-mass network model, was used to im...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797106026143547392 |
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| author | Brown, C Houle, M Chen, M Price, A Légaré, F Gill, H |
| author_facet | Brown, C Houle, M Chen, M Price, A Légaré, F Gill, H |
| author_sort | Brown, C |
| collection | OXFORD |
| description | With increasing interest in treating osteoarthritis at its earliest stages, it has become important to understand the mechanisms by which the disease progresses across a joint. Here, second harmonic generation (SHG) microscopy, coupled with a two-dimensional spring-mass network model, was used to image and investigate the collagen meshwork architecture at the cartilage surface surrounding osteoarthritic lesions. We found that minor weakening of the collagen meshwork leads to the bundling of fibrils at the surface under normal loading. This bundling appears to be an irreversible step in the degradation process, as the stress concentrations drive the progression of damage, forming larger bundles and cracks that eventually form lesions. |
| first_indexed | 2024-03-07T06:55:49Z |
| format | Journal article |
| id | oxford-uuid:fe1ca9dc-388c-4aab-9a78-a1ebd8de887f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:55:49Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:fe1ca9dc-388c-4aab-9a78-a1ebd8de887f2022-03-27T13:33:52ZDamage initiation and progression in the cartilage surface probed by nonlinear optical microscopy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fe1ca9dc-388c-4aab-9a78-a1ebd8de887fEnglishSymplectic Elements at Oxford2012Brown, CHoule, MChen, MPrice, ALégaré, FGill, HWith increasing interest in treating osteoarthritis at its earliest stages, it has become important to understand the mechanisms by which the disease progresses across a joint. Here, second harmonic generation (SHG) microscopy, coupled with a two-dimensional spring-mass network model, was used to image and investigate the collagen meshwork architecture at the cartilage surface surrounding osteoarthritic lesions. We found that minor weakening of the collagen meshwork leads to the bundling of fibrils at the surface under normal loading. This bundling appears to be an irreversible step in the degradation process, as the stress concentrations drive the progression of damage, forming larger bundles and cracks that eventually form lesions. |
| spellingShingle | Brown, C Houle, M Chen, M Price, A Légaré, F Gill, H Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy. |
| title | Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy. |
| title_full | Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy. |
| title_fullStr | Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy. |
| title_full_unstemmed | Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy. |
| title_short | Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy. |
| title_sort | damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy |
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