Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells.
Replicating viruses have broad applications in biomedicine, notably in cancer virotherapy and in the design of attenuated vaccines; however, uncontrolled virus replication in vulnerable tissues can give pathology and often restricts the use of potent strains. Increased knowledge of tissue-selective...
मुख्य लेखकों: | Cawood, R, Chen, H, Carroll, F, Bazan-Peregrino, M, van Rooijen, N, Seymour, L |
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स्वरूप: | Journal article |
भाषा: | English |
प्रकाशित: |
2009
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समान संसाधन
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Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells.
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MicroRNA controlled adenovirus mediates anti-cancer efficacy without affecting endogenous microRNA activity.
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Liver specific microRNA control of adenovirus serotype five
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Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination
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Factors influencing retention of adenovirus within tumours following direct intratumoural injection.
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