Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa
Hypertrophic cardiomyopathy (HCM) affects up to 1 in 500 of the population and is the commonest cause of sudden death in the younger population. However, its pathophysiology and mechanisms of progression are not fully understood. The underlying sarcomere mutations increase the energy cost of contrac...
| Main Authors: | , , , , , , , , , |
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| Format: | Conference item |
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American Heart Association
2015
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| _version_ | 1797106055835025408 |
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| author | Dass, S Cochlin, L Suttie, J Holloway, C Rodgers, C Tyler, D Karamitsos, T Clarke, K Watkins, H Neubauer, S |
| author_facet | Dass, S Cochlin, L Suttie, J Holloway, C Rodgers, C Tyler, D Karamitsos, T Clarke, K Watkins, H Neubauer, S |
| author_sort | Dass, S |
| collection | OXFORD |
| description | Hypertrophic cardiomyopathy (HCM) affects up to 1 in 500 of the population and is the commonest cause of sudden death in the younger population. However, its pathophysiology and mechanisms of progression are not fully understood. The underlying sarcomere mutations increase the energy cost of contraction, and impaired resting energetics (i.e. phosphocreatine/adenosine triphosphate, PCr/ATP, as measured by 31Phosphorus MR Spectroscopy, 31P MRS) has been documented in genetically modified animal models and in patients with HCM.Hypothesis: Our hypothesis is that the high incidence of exercise-related death in HCM may be explained by an acute impairment of myocardial energetics. As a proof-of-principle study, we examined whether cardiac energetics are further impaired during exercise in HCM. |
| first_indexed | 2024-03-07T06:56:15Z |
| format | Conference item |
| id | oxford-uuid:fe3cd738-ba00-4a14-a225-f2b3fb62711d |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:56:15Z |
| publishDate | 2015 |
| publisher | American Heart Association |
| record_format | dspace |
| spelling | oxford-uuid:fe3cd738-ba00-4a14-a225-f2b3fb62711d2022-03-27T13:34:49ZExercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 TelsaConference itemhttp://purl.org/coar/resource_type/c_5794uuid:fe3cd738-ba00-4a14-a225-f2b3fb62711dSymplectic Elements at OxfordAmerican Heart Association2015Dass, SCochlin, LSuttie, JHolloway, CRodgers, CTyler, DKaramitsos, TClarke, KWatkins, HNeubauer, SHypertrophic cardiomyopathy (HCM) affects up to 1 in 500 of the population and is the commonest cause of sudden death in the younger population. However, its pathophysiology and mechanisms of progression are not fully understood. The underlying sarcomere mutations increase the energy cost of contraction, and impaired resting energetics (i.e. phosphocreatine/adenosine triphosphate, PCr/ATP, as measured by 31Phosphorus MR Spectroscopy, 31P MRS) has been documented in genetically modified animal models and in patients with HCM.Hypothesis: Our hypothesis is that the high incidence of exercise-related death in HCM may be explained by an acute impairment of myocardial energetics. As a proof-of-principle study, we examined whether cardiac energetics are further impaired during exercise in HCM. |
| spellingShingle | Dass, S Cochlin, L Suttie, J Holloway, C Rodgers, C Tyler, D Karamitsos, T Clarke, K Watkins, H Neubauer, S Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa |
| title | Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa |
| title_full | Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa |
| title_fullStr | Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa |
| title_full_unstemmed | Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa |
| title_short | Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa |
| title_sort | exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy a 31 phosphorus magnetic resonance study at 3 telsa |
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