Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa

Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy, a 31 phosphorus magnetic resonance study at 3 Telsa

Hypertrophic cardiomyopathy (HCM) affects up to 1 in 500 of the population and is the commonest cause of sudden death in the younger population. However, its pathophysiology and mechanisms of progression are not fully understood. The underlying sarcomere mutations increase the energy cost of contrac...

Full description

Bibliographic Details
Main Authors:	Dass, S, Cochlin, L, Suttie, J, Holloway, C, Rodgers, C, Tyler, D, Karamitsos, T, Clarke, K, Watkins, H, Neubauer, S
Format:	Conference item
Published:	American Heart Association 2015

Similar Items

Derangement of cardiac energy metabolism is acutely exacerbated during exercise in hypertrophic cardiomyopathy, independent of hypertrophy or late gadolinium burden
by: Dass, S, et al.
Published: (2012)

ACUTE DERANGEMENT OF CARDIAC ENERGY METABOLISM AND OXYGENATION DURING STRESS IN HYPERTROPHIC CARDIOMYOPATHY-A POTENTIAL MECHANISM FOR SUDDEN CARDIAC DEATH
by: Dass, S, et al.
Published: (2012)

Myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy.
by: Dass, S, et al.
Published: (2012)

Blunted myocardial oxygenation response during vasodilator stress in patients with hypertrophic cardiomyopathy.
by: Karamitsos, T, et al.
Published: (2013)

Non-contrast T1 mapping characterizes the myocardium beyond that achieved by late gadolinium enhancement in both hypertrophic and dilated cardiomyopathy.
by: Dass, S, et al.
Published: (2012)

Response to letter regarding article, "myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy".
by: Dass, S, et al.
Published: (2013)

Obesity-related ventricular remodelling is exacerbated in dilated and hypertrophic cardiomyopathy
by: Rayner, JJ, et al.
Published: (2020)

Cardiac Steatosis Detected in Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy and Aortic Stenosis
by: Suttie, J, et al.
Published: (2011)

In Both Hypertrophic And Dilated Cardiomyopathy, Non-contrast T1 Mapping Provides Myocardial Tissue Characterization Beyond That Achieved By Late Gadolinium Enhancement.
by: Dass, S, et al.
Published: (2011)

Dilated Cardiomyopathy: Phosphorus 31 MR Spectroscopy at 7 T
by: Stoll, V, et al.
Published: (2016)

Patients with hypertrophic cardiomyopathy (HCM) and HCM gene carriers have attenuated myocardial oxygenation response to vasodilator stress - a potential mechanism for sudden cardiac death.
by: Dass, S, et al.
Published: (2012)

Exercise training in dilated cardiomyopathy improves rest and stress cardiac function without changes in cardiac high energy phosphate metabolism.
by: Holloway, C, et al.
Published: (2012)

Hypertrophic cardiomyopathy in Noonan Syndrome closely mimics familial hypertrophic cardiomyopathy due to sarcomeric mutations.
by: Hudsmith, L, et al.
Published: (2006)

Sudden death in hypertrophic cardiomyopathy.
by: Watkins, H
Published: (2000)

Myocardial dysfunction in hypertrophic cardiomyopathy.
by: Ashrafian, H, et al.
Published: (2001)

Exercise-induced ventricular dysfunction in hypertrophic cardiomyopathy: stunning by any other name?
by: Ashrafian, H, et al.
Published: (2008)

Reproducibility of 31-phosphorus cardiac magnetic resonance spectroscopy at 3 Tesla
by: Emmanuel, Y, et al.
Published: (2008)

Effects of propranolol on response to exercise in hypertrophic obstructive cardiomyopathy.
by: Edwards, R, et al.
Published: (1970)

EFFECTS OF PROPRANOLOL ON RESPONSE TO EXERCISE IN HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY
by: Edwards, R, et al.
Published: (1970)

Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications
by: Raman, B, et al.
Published: (2018)

Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy
by: Ashrafian, H, et al.
Published: (2005)

The role of cardiac energy metabolism and during stress in hypertrophic and dilated cardiomyopathy.
by: Dass, S
Published: (2012)

Hypertrophic cardiomyopathy complicated by large apical aneurysm and thrombus, presenting as ventricular tachycardia.
by: Holloway, C, et al.
Published: (2010)

The genetics of hypertrophic cardiomyopathy: Teare redux.
by: Watkins, H, et al.
Published: (2008)

Impaired left ventricular energy metabolism in hypertrophic cardiomyopathy is not due to fibrosis.
by: Petersen, SE, et al.
Published: (2009)

Measuring inorganic phosphate and intracellular pH in the healthy and hypertrophic cardiomyopathy hearts by in vivo 7T 31P-cardiovascular magnetic resonance spectroscopy
by: Valkovič, L, et al.
Published: (2019)

Linked genetic modifiers in hypertrophic cardiomyopathy
by: Ektisham, J, et al.
Published: (2004)

Correlates of myocardial fibrosis in hypertrophic cardiomyopathy
by: Kramer, CM, et al.
Published: (2018)

Genetic clues to disease pathways in hypertrophic and dilated cardiomyopathies.
by: Watkins, H
Published: (2003)

Predictors of atrial emptying function in patients with hypertrophic cardiomyopathy: insights from cardiovascular magnetic resonance.
by: Tanacli, R, et al.
Published: (2012)

The prognostic impact of septal myectomy in obstructive hypertrophic cardiomyopathy.
by: Watkins, H, et al.
Published: (2005)

The genetic architecture of hypertrophic cardiomyopathy
by: Harper, AR
Published: (2020)

Is DNA testing for hypertrophic cardiomyopathy cost-effective?
by: Wordsworth, S, et al.
Published: (2006)

Ascertainment strategies and genotype:phenotype correlations in hypertrophic cardiomyopathy.
by: Blair, E, et al.
Published: (2003)

Metabolic Modulation With Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy
by: Abozguia, K, et al.
Published: (2009)

Hypertrophic cardiomyopathy: from molecular and genetic mechanisms to clinical management
by: Watkins, H
Published: (2001)

Assigning a causal role to genetic variants in hypertrophic cardiomyopathy.
by: Watkins, H
Published: (2013)

Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy.
by: Ashrafian, H, et al.
Published: (2011)

Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy.
by: Abozguia, K, et al.
Published: (2010)

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.
by: Ashrafian, H, et al.
Published: (2003)