Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria.
Extracellular release of granzymes is considered to reflect the involvement of cytotoxic T lymphocytes and NK cells in various disease states. To obtain insight into granzyme release during bacterial infection, granzyme levels were measured during experimental human endotoxemia and in patients with...
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2000
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| _version_ | 1826306995603374080 |
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| author | Lauw, F Simpson, A Hack, C Prins, J Wolbink, A van Deventer, S Chaowagul, W White, N van Der Poll, T |
| author_facet | Lauw, F Simpson, A Hack, C Prins, J Wolbink, A van Deventer, S Chaowagul, W White, N van Der Poll, T |
| author_sort | Lauw, F |
| collection | OXFORD |
| description | Extracellular release of granzymes is considered to reflect the involvement of cytotoxic T lymphocytes and NK cells in various disease states. To obtain insight into granzyme release during bacterial infection, granzyme levels were measured during experimental human endotoxemia and in patients with melioidosis, a severe infection due to gram-negative bacteria. Plasma concentrations of granzyme A (GrA) and GrB increased transiently after endotoxin administration, peaking after 2-6 h. In patients with bacteremic melioidosis, GrA and GrB levels were elevated on admission and remained high during the 72-h study period. In whole blood stimulated with heat-killed Burkholderia pseudomallei, neutralization of tumor necrosis factor, interleukin-12, or interleukin-18 inhibited granzyme secretion, which was independent of interferon-gamma. Stimulation with endotoxin and other gram-negative and gram-positive bacteria also strongly induced the secretion of granzymes, suggesting that granzyme release is a general immune response during bacterial infection. The interaction between the cytokine network and granzymes may play an important immunoregulatory role during bacterial infections. |
| first_indexed | 2024-03-07T06:56:22Z |
| format | Journal article |
| id | oxford-uuid:fe45bbe3-bcbc-4a86-84a6-cacb0103bd58 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:56:22Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:fe45bbe3-bcbc-4a86-84a6-cacb0103bd582022-03-27T13:35:04ZSoluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fe45bbe3-bcbc-4a86-84a6-cacb0103bd58EnglishSymplectic Elements at Oxford2000Lauw, FSimpson, AHack, CPrins, JWolbink, Avan Deventer, SChaowagul, WWhite, Nvan Der Poll, TExtracellular release of granzymes is considered to reflect the involvement of cytotoxic T lymphocytes and NK cells in various disease states. To obtain insight into granzyme release during bacterial infection, granzyme levels were measured during experimental human endotoxemia and in patients with melioidosis, a severe infection due to gram-negative bacteria. Plasma concentrations of granzyme A (GrA) and GrB increased transiently after endotoxin administration, peaking after 2-6 h. In patients with bacteremic melioidosis, GrA and GrB levels were elevated on admission and remained high during the 72-h study period. In whole blood stimulated with heat-killed Burkholderia pseudomallei, neutralization of tumor necrosis factor, interleukin-12, or interleukin-18 inhibited granzyme secretion, which was independent of interferon-gamma. Stimulation with endotoxin and other gram-negative and gram-positive bacteria also strongly induced the secretion of granzymes, suggesting that granzyme release is a general immune response during bacterial infection. The interaction between the cytokine network and granzymes may play an important immunoregulatory role during bacterial infections. |
| spellingShingle | Lauw, F Simpson, A Hack, C Prins, J Wolbink, A van Deventer, S Chaowagul, W White, N van Der Poll, T Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. |
| title | Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. |
| title_full | Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. |
| title_fullStr | Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. |
| title_full_unstemmed | Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. |
| title_short | Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. |
| title_sort | soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram negative bacteria |
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