Antibody seroconversion in asymptomatic andsymptomatic patients infected with severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2)
<strong>Objectives</strong> Asymptomatic and symptomatic patients may transmit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), but their clinical features and immune responses remain largely unclear. We aimed to characterise the clinical features and immune responses of asy...
| المؤلفون الرئيسيون: | , , , , , , , , , , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Wiley
2020
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| _version_ | 1826306997376516096 |
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| author | Jiang, C Wang, Y Hu, M Wen, L Wen, C Wang, Y Zhu, W Tai, S Jiang, Z Xiao, K Faria, NR De Clercq, E Xu, J Li, G |
| author_facet | Jiang, C Wang, Y Hu, M Wen, L Wen, C Wang, Y Zhu, W Tai, S Jiang, Z Xiao, K Faria, NR De Clercq, E Xu, J Li, G |
| author_sort | Jiang, C |
| collection | OXFORD |
| description | <strong>Objectives</strong>
Asymptomatic and symptomatic patients may transmit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), but their clinical features and immune responses remain largely unclear. We aimed to characterise the clinical features and immune responses of asymptomatic and symptomatic patients infected with SARS‐CoV‐2.
<br>
<strong>Methods</strong>
We collected clinical, laboratory and epidemiological records of patients hospitalised in a coronavirus field hospital in Wuhan. We performed qualitative detection of anti‐SARS‐CoV‐2 immunoglobulin M (IgM) and immunoglobulin G (IgG) using archived blood samples.
<br>
<strong>Results</strong>
Of 214 patients with SARS‐CoV‐2, 26 (12%) were asymptomatic at hospital admission and during hospitalisation. Most asymptomatic patients were ≤ 60 years (96%) and females (65%) and had few comorbidities (< 16%). Serum levels of white and red blood cells were higher in asymptomatic than in symptomatic patients (P‐values < 0.05). During hospitalisation, IgG seroconversion was commonly observed in both asymptomatic and symptomatic patients (85% versus 94%, P‐value = 0.07); in contrast, IgM seroconversion was less common in asymptomatic than in symptomatic patients (31% versus 74%, P‐value < 0.001). The median time from the first virus‐positive screening to IgG or IgM seroconversion was significantly shorter in asymptomatic than in symptomatic patients (median: 7 versus 14 days, P‐value < 0.01). Furthermore, IgG/IgM seroconversion rates increased concomitantly with the clearance of SARS‐CoV‐2 in both asymptomatic and symptomatic patients. At the time of virus clearance, IgG/IgM titres and plasma neutralisation capacity were significantly lower in recovered asymptomatic than in recovered symptomatic patients (P‐values < 0.01).
<br>
<strong>Conclusion</strong>
Asymptomatic and symptomatic patients exhibited different kinetics of IgG/IgM responses to SARS‐CoV‐2. Asymptomatic patients may transmit SARS‐CoV‐2, highlighting the importance of early diagnosis and treatment. |
| first_indexed | 2024-03-07T06:56:23Z |
| format | Journal article |
| id | oxford-uuid:fe47b28b-b84a-4b72-b19d-0daa0dd5dbd0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:56:23Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:fe47b28b-b84a-4b72-b19d-0daa0dd5dbd02022-03-27T13:35:15ZAntibody seroconversion in asymptomatic andsymptomatic patients infected with severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fe47b28b-b84a-4b72-b19d-0daa0dd5dbd0EnglishSymplectic ElementsWiley2020Jiang, CWang, YHu, MWen, LWen, CWang, YZhu, WTai, SJiang, ZXiao, KFaria, NRDe Clercq, EXu, JLi, G<strong>Objectives</strong> Asymptomatic and symptomatic patients may transmit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), but their clinical features and immune responses remain largely unclear. We aimed to characterise the clinical features and immune responses of asymptomatic and symptomatic patients infected with SARS‐CoV‐2. <br> <strong>Methods</strong> We collected clinical, laboratory and epidemiological records of patients hospitalised in a coronavirus field hospital in Wuhan. We performed qualitative detection of anti‐SARS‐CoV‐2 immunoglobulin M (IgM) and immunoglobulin G (IgG) using archived blood samples. <br> <strong>Results</strong> Of 214 patients with SARS‐CoV‐2, 26 (12%) were asymptomatic at hospital admission and during hospitalisation. Most asymptomatic patients were ≤ 60 years (96%) and females (65%) and had few comorbidities (< 16%). Serum levels of white and red blood cells were higher in asymptomatic than in symptomatic patients (P‐values < 0.05). During hospitalisation, IgG seroconversion was commonly observed in both asymptomatic and symptomatic patients (85% versus 94%, P‐value = 0.07); in contrast, IgM seroconversion was less common in asymptomatic than in symptomatic patients (31% versus 74%, P‐value < 0.001). The median time from the first virus‐positive screening to IgG or IgM seroconversion was significantly shorter in asymptomatic than in symptomatic patients (median: 7 versus 14 days, P‐value < 0.01). Furthermore, IgG/IgM seroconversion rates increased concomitantly with the clearance of SARS‐CoV‐2 in both asymptomatic and symptomatic patients. At the time of virus clearance, IgG/IgM titres and plasma neutralisation capacity were significantly lower in recovered asymptomatic than in recovered symptomatic patients (P‐values < 0.01). <br> <strong>Conclusion</strong> Asymptomatic and symptomatic patients exhibited different kinetics of IgG/IgM responses to SARS‐CoV‐2. Asymptomatic patients may transmit SARS‐CoV‐2, highlighting the importance of early diagnosis and treatment. |
| spellingShingle | Jiang, C Wang, Y Hu, M Wen, L Wen, C Wang, Y Zhu, W Tai, S Jiang, Z Xiao, K Faria, NR De Clercq, E Xu, J Li, G Antibody seroconversion in asymptomatic andsymptomatic patients infected with severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) |
| title | Antibody seroconversion in asymptomatic andsymptomatic patients infected with severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) |
| title_full | Antibody seroconversion in asymptomatic andsymptomatic patients infected with severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) |
| title_fullStr | Antibody seroconversion in asymptomatic andsymptomatic patients infected with severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) |
| title_full_unstemmed | Antibody seroconversion in asymptomatic andsymptomatic patients infected with severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) |
| title_short | Antibody seroconversion in asymptomatic andsymptomatic patients infected with severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) |
| title_sort | antibody seroconversion in asymptomatic andsymptomatic patients infected with severe acuterespiratory syndrome coronavirus 2 sars cov 2 |
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