Investigating the effects of cGAS-STING-dependent innate immune responses in BRCA2-deficient cells
<p>Tumours with BRCA2 gene deficiency, retain the ability to proliferate, despite the genomic instability resulting from DNA damage accumulation. These tumours can be targeted with Poly-ADP ribose polymerase inhibitors (PARPi), which increase the susceptibility of BRCA2-mutated tumours to DNA...
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| Format: | Thesis |
| Language: | English |
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2022
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