HLA-DRB1 and month of birth in multiple sclerosis.
BACKGROUND: Multiple sclerosis (MS) displays a month-of-birth effect, with an excess of individuals being born in the spring and a deficit in the winter. This effect was shown to be more pronounced in familial cases of MS. In the present study, we investigated whether this month-of-birth associatio...
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2009
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| _version_ | 1826307030946676736 |
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| author | Ramagopalan, S Link, J Byrnes, J Dyment, D Giovannoni, G Hintzen, R Sundqvist, E Kockum, I Smestad, C Lie, B Harbo, H Padyukov, L Alfredsson, L Olsson, T Sadovnick, A Hillert, J Ebers, G |
| author_facet | Ramagopalan, S Link, J Byrnes, J Dyment, D Giovannoni, G Hintzen, R Sundqvist, E Kockum, I Smestad, C Lie, B Harbo, H Padyukov, L Alfredsson, L Olsson, T Sadovnick, A Hillert, J Ebers, G |
| author_sort | Ramagopalan, S |
| collection | OXFORD |
| description | BACKGROUND: Multiple sclerosis (MS) displays a month-of-birth effect, with an excess of individuals being born in the spring and a deficit in the winter. This effect was shown to be more pronounced in familial cases of MS. In the present study, we investigated whether this month-of-birth association has any relation to the principal MS susceptibility gene, HLA-DRB1. METHODS: A total of 4,834 patients with MS, 4,056 controls, and 659 unaffected siblings from Canada, Sweden, and Norway were genotyped for the HLA-DRB1 gene. Month of birth was compared for patients, controls, and unaffected siblings with and without the MS risk allele HLA-DRB1*15. RESULTS: Significantly fewer patients with MS carrying the HLA-DRB1*15 risk allele were born in November compared with patients not carrying this allele (p = 0.02). Additionally, patients with MS carrying HLA-DRB1*15 had a higher number of April births compared with patients with MS not carrying HLA-DRB1*15 (p = 0.004). These differences were not present in controls or unaffected siblings. CONCLUSIONS: Month of birth, HLA-DRB1 genotype, and risk of multiple sclerosis are associated. The interaction of a seasonal risk factor with loci at or near HLA-DRB1 during gestation or shortly after birth is implicated. |
| first_indexed | 2024-03-07T06:56:54Z |
| format | Journal article |
| id | oxford-uuid:fe6ff7f3-5bc1-4d69-be21-0c1a586123db |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:56:54Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:fe6ff7f3-5bc1-4d69-be21-0c1a586123db2022-03-27T13:36:30ZHLA-DRB1 and month of birth in multiple sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fe6ff7f3-5bc1-4d69-be21-0c1a586123dbEnglishSymplectic Elements at Oxford2009Ramagopalan, SLink, JByrnes, JDyment, DGiovannoni, GHintzen, RSundqvist, EKockum, ISmestad, CLie, BHarbo, HPadyukov, LAlfredsson, LOlsson, TSadovnick, AHillert, JEbers, G BACKGROUND: Multiple sclerosis (MS) displays a month-of-birth effect, with an excess of individuals being born in the spring and a deficit in the winter. This effect was shown to be more pronounced in familial cases of MS. In the present study, we investigated whether this month-of-birth association has any relation to the principal MS susceptibility gene, HLA-DRB1. METHODS: A total of 4,834 patients with MS, 4,056 controls, and 659 unaffected siblings from Canada, Sweden, and Norway were genotyped for the HLA-DRB1 gene. Month of birth was compared for patients, controls, and unaffected siblings with and without the MS risk allele HLA-DRB1*15. RESULTS: Significantly fewer patients with MS carrying the HLA-DRB1*15 risk allele were born in November compared with patients not carrying this allele (p = 0.02). Additionally, patients with MS carrying HLA-DRB1*15 had a higher number of April births compared with patients with MS not carrying HLA-DRB1*15 (p = 0.004). These differences were not present in controls or unaffected siblings. CONCLUSIONS: Month of birth, HLA-DRB1 genotype, and risk of multiple sclerosis are associated. The interaction of a seasonal risk factor with loci at or near HLA-DRB1 during gestation or shortly after birth is implicated. |
| spellingShingle | Ramagopalan, S Link, J Byrnes, J Dyment, D Giovannoni, G Hintzen, R Sundqvist, E Kockum, I Smestad, C Lie, B Harbo, H Padyukov, L Alfredsson, L Olsson, T Sadovnick, A Hillert, J Ebers, G HLA-DRB1 and month of birth in multiple sclerosis. |
| title | HLA-DRB1 and month of birth in multiple sclerosis. |
| title_full | HLA-DRB1 and month of birth in multiple sclerosis. |
| title_fullStr | HLA-DRB1 and month of birth in multiple sclerosis. |
| title_full_unstemmed | HLA-DRB1 and month of birth in multiple sclerosis. |
| title_short | HLA-DRB1 and month of birth in multiple sclerosis. |
| title_sort | hla drb1 and month of birth in multiple sclerosis |
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