Development of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countries
Current pediatric antibiotic therapies often use oral and parenteral routes of administration. Neither are suitable for treating very sick neonates who cannot take oral medication and may be several hours away from hospital in developing countries. Here, we report on the development of rectal forms...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2019
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| _version_ | 1797106111127486464 |
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| author | Kauss, T Langlois, M-H Guyonnet-Dupérat, A Phoeung, T Xie, XY Cartwright, A White, N Gomes, M Gaudin, K |
| author_facet | Kauss, T Langlois, M-H Guyonnet-Dupérat, A Phoeung, T Xie, XY Cartwright, A White, N Gomes, M Gaudin, K |
| author_sort | Kauss, T |
| collection | OXFORD |
| description | Current pediatric antibiotic therapies often use oral and parenteral routes of administration. Neither are suitable for treating very sick neonates who cannot take oral medication and may be several hours away from hospital in developing countries. Here, we report on the development of rectal forms of ceftriaxone, a third-generation cephalosporin. Rectodispersible tablets and capsules were developed and successfully passed 6-month accelerated stability tests. Rabbit bioavailability showed plasma concentrations above the minimal inhibitory concentrations for 3 formulations of rectodispersible tablets and 2 formulations of hard capsules. Clinical batches are currently being prepared for human evaluation with the prospect of offering therapeutic alternatives for treating critically ill neonates. This proof of concept for efficient rectal delivery of antibiotics could help the development of other rectal antibiotic treatments and increase options for noninvasive drug development for pediatric patients. |
| first_indexed | 2024-03-07T06:57:04Z |
| format | Journal article |
| id | oxford-uuid:fe7cc5dd-2c5f-4ddf-b98c-0761ba492579 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:57:04Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:fe7cc5dd-2c5f-4ddf-b98c-0761ba4925792022-03-27T13:37:33ZDevelopment of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countriesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fe7cc5dd-2c5f-4ddf-b98c-0761ba492579EnglishSymplectic Elements at OxfordElsevier2019Kauss, TLanglois, M-HGuyonnet-Dupérat, APhoeung, TXie, XYCartwright, AWhite, NGomes, MGaudin, KCurrent pediatric antibiotic therapies often use oral and parenteral routes of administration. Neither are suitable for treating very sick neonates who cannot take oral medication and may be several hours away from hospital in developing countries. Here, we report on the development of rectal forms of ceftriaxone, a third-generation cephalosporin. Rectodispersible tablets and capsules were developed and successfully passed 6-month accelerated stability tests. Rabbit bioavailability showed plasma concentrations above the minimal inhibitory concentrations for 3 formulations of rectodispersible tablets and 2 formulations of hard capsules. Clinical batches are currently being prepared for human evaluation with the prospect of offering therapeutic alternatives for treating critically ill neonates. This proof of concept for efficient rectal delivery of antibiotics could help the development of other rectal antibiotic treatments and increase options for noninvasive drug development for pediatric patients. |
| spellingShingle | Kauss, T Langlois, M-H Guyonnet-Dupérat, A Phoeung, T Xie, XY Cartwright, A White, N Gomes, M Gaudin, K Development of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countries |
| title | Development of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countries |
| title_full | Development of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countries |
| title_fullStr | Development of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countries |
| title_full_unstemmed | Development of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countries |
| title_short | Development of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countries |
| title_sort | development of rectodispersible tablets and granulate capsules for the treatment of serious neonatal sepsis in developing countries |
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