Targeting the mevalonate pathway for pharmacological intervention

Targeting the mevalonate pathway for pharmacological intervention

Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway and the main molecular target of nitrogen-containing bisphosphonates (N-BPs), potent inhibitors of osteoclastic activity and the leading drug of choice for conditions characterized by excessive bone resorpt...

Descripció completa

Dades bibliogràfiques
Autor principal:	Tsoumpra, M
Altres autors:	Russell, R
Format:	Thesis
Idioma:	English
Publicat:	2011
Matèries:	Crystallography Chemical kinetics Pharmacology Enzymes Structural chemistry Biochemistry

Ítems similars

Biochemical and structural studies of metallo-β-lactamase superfamily enzymes
per: Skorupskaite, A
Publicat: (2019)

Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases
per: Tarhonskaya, H
Publicat: (2014)

Radiation damage in protein crystallography: susceptibility study
per: Gerstel, M
Publicat: (2014)

CRYSTALS enhancements: asymmetric restraints
per: Cooper, R, et al.
Publicat: (2012)

Identifying and quantifying radiation damage at the atomic level
per: Gerstel, M, et al.
Publicat: (2015)

Pharmacological and structural studies on the hedgehog pathway receptor smoothened
per: Klindert, S
Publicat: (2023)

Studies on ribosomal oxygenases
per: Sekirnik, R
Publicat: (2014)

Chiral selection in the formation of borates from racemic binaphthols and related diols
per: Raskatov, J, et al.
Publicat: (2011)

Structure and function of bacterial proteins secreted by the type three secretion and twin arginine translocation pathways
per: Lillington, J, et al.
Publicat: (2011)

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
per: Pfeffer, I
Publicat: (2014)

Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation
per: Yuhong Zuo, et al.
Publicat: (2020-09-01)

The synthesis and characterisation of metal complexes containing chemically reduced bipyridyl ligand systems
per: Irwin, M
Publicat: (2013)

Determining structure and atomic properties of materials using resonant x-ray diffraction
per: Sutton, K
Publicat: (2015)

Computational studies of ligand-water mediated interactions in ionotropic glutamate receptors
per: Sahai, M
Publicat: (2011)

Structural studies of peptide binding to chicken class I MHC molecules, the CD6-CD166 interaction and enzymes involved in bacterial sulfur metabolism
per: Chappell, P
Publicat: (2015)

Ribosome engineering to promote new crystal forms
per: Ramakrishnan, V., et al.
Publicat: (2013)

Crystallization and preliminary X-ray crystallographic analysis of subunit F (F1-94), an essential coupling subunit of the eukaryotic V1VO-ATPase from Saccharomyces cerevisiae
per: Basak, Sandip, et al.
Publicat: (2013)

Diverse reactivity of a tricoordinate organoboron L2PhB: (L = oxazol-2-ylidene) towards alkali metal, group 9 metal, and coinage metal precursors
per: Kong, Lingbing, et al.
Publicat: (2015)

Synthesis of metal complex crystals of bisisoquenolines derivatives and their x-ray crystallography
per: Teng, Jun Boon.
Publicat: (2010)

Structure-property relationships in framework materials: anomalous mechanics by design
per: Collings, I, et al.
Publicat: (2014)

Local structure/property relationships in functional materials
per: Young, CA
Publicat: (2014)

Crystallographic studies on 2-oxoglutarate dependent oxygenases
per: Aik, WS
Publicat: (2014)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
per: Marles-Wright, J
Publicat: (2005)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
per: Marles-Wright, J
Publicat: (2005)

Structural studies of cell adhesion and division
per: Yates, LA
Publicat: (2012)

Structure of the RNA-dependent RNA polymerase from influenza C virus
per: Hengrung, N
Publicat: (2014)

Investigation of X-ray induced radiation damage in proteins, nucleic acids and their complexes
per: Bury, C
Publicat: (2017)

Protein-protein recognition in biological systems exhibiting highly-conserved tertiary structure: cytochrome P450
per: Johnson, E, et al.
Publicat: (2013)

Investigating high-affinity non-covalent protein-ligand interaction via variants of streptavidin
per: Chivers, C
Publicat: (2011)

Effect of annealing temperature on microstructure and UV light photocatalytic activity of TiO2 films grown by atmospheric pressure CVD
per: Soutar, Andrew McIntosh, et al.
Publicat: (2015)

Structural and mechanistic studies on prolyl hydroxylases
per: Chowdhury, R
Publicat: (2008)

Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-hydroxymethyl- 5-methyloctahydroindolizine-1,2- diol hydrobromide]
per: Thompson, A, et al.
Publicat: (2009)

Three dimensional QSAR : applications in pharmacology and toxicology /
per: 505265 Doucet, Jean-Pierre, et al.
Publicat: (2010)

Pharmacological targeting of Sam68 functions in colorectal cancer stem cells
per: Angelique N. Masibag, et al.
Publicat: (2021-12-01)

Small molecule colorimetric and fluorescent probes for specific protein detection
per: Egleton, JE
Publicat: (2015)

Sulfonamide supported catalysts for the ring opening polymerisation of cyclic esters
per: Schwarz, A
Publicat: (2010)

Structural chemistry of transition metal dicyanometallates
per: Hill, J
Publicat: (2016)

The crystal chemistry and hydrogen storage properties of light metal borohydrides
per: Culligan, SD
Publicat: (2013)

Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes
per: Jungin Kwon, et al.
Publicat: (2023-03-01)

High density ammonia storage materials
per: Royse, D, et al.
Publicat: (2011)