Targeting the mevalonate pathway for pharmacological intervention

Targeting the mevalonate pathway for pharmacological intervention

Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway and the main molecular target of nitrogen-containing bisphosphonates (N-BPs), potent inhibitors of osteoclastic activity and the leading drug of choice for conditions characterized by excessive bone resorpt...

Podrobná bibliografie
Hlavní autor:	Tsoumpra, M
Další autoři:	Russell, R
Médium:	Diplomová práce
Jazyk:	English
Vydáno:	2011
Témata:	Crystallography Chemical kinetics Pharmacology Enzymes Structural chemistry Biochemistry

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