Targeting the mevalonate pathway for pharmacological intervention

Targeting the mevalonate pathway for pharmacological intervention

Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway and the main molecular target of nitrogen-containing bisphosphonates (N-BPs), potent inhibitors of osteoclastic activity and the leading drug of choice for conditions characterized by excessive bone resorpt...

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Bibliografische gegevens
Hoofdauteur:	Tsoumpra, M
Andere auteurs:	Russell, R
Formaat:	Thesis
Taal:	English
Gepubliceerd in:	2011
Onderwerpen:	Crystallography Chemical kinetics Pharmacology Enzymes Structural chemistry Biochemistry

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