Targeting the mevalonate pathway for pharmacological intervention

Targeting the mevalonate pathway for pharmacological intervention

Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway and the main molecular target of nitrogen-containing bisphosphonates (N-BPs), potent inhibitors of osteoclastic activity and the leading drug of choice for conditions characterized by excessive bone resorpt...

書目詳細資料
主要作者:	Tsoumpra, M
其他作者:	Russell, R
格式:	Thesis
語言:	English
出版:	2011
主題:	Crystallography Chemical kinetics Pharmacology Enzymes Structural chemistry Biochemistry

相似書籍

Biochemical and structural studies of metallo-β-lactamase superfamily enzymes
由: Skorupskaite, A
出版: (2019)

Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases
由: Tarhonskaya, H
出版: (2014)

Radiation damage in protein crystallography: susceptibility study
由: Gerstel, M
出版: (2014)

CRYSTALS enhancements: asymmetric restraints
由: Cooper, R, et al.
出版: (2012)

Identifying and quantifying radiation damage at the atomic level
由: Gerstel, M, et al.
出版: (2015)

Pharmacological and structural studies on the hedgehog pathway receptor smoothened
由: Klindert, S
出版: (2023)

Studies on ribosomal oxygenases
由: Sekirnik, R
出版: (2014)

Chiral selection in the formation of borates from racemic binaphthols and related diols
由: Raskatov, J, et al.
出版: (2011)

Structure and function of bacterial proteins secreted by the type three secretion and twin arginine translocation pathways
由: Lillington, J, et al.
出版: (2011)

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
由: Pfeffer, I
出版: (2014)

Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation
由: Yuhong Zuo, et al.
出版: (2020-09-01)

The synthesis and characterisation of metal complexes containing chemically reduced bipyridyl ligand systems
由: Irwin, M
出版: (2013)

Determining structure and atomic properties of materials using resonant x-ray diffraction
由: Sutton, K
出版: (2015)

Computational studies of ligand-water mediated interactions in ionotropic glutamate receptors
由: Sahai, M
出版: (2011)

Structural studies of peptide binding to chicken class I MHC molecules, the CD6-CD166 interaction and enzymes involved in bacterial sulfur metabolism
由: Chappell, P
出版: (2015)

Ribosome engineering to promote new crystal forms
由: Ramakrishnan, V., et al.
出版: (2013)

Crystallization and preliminary X-ray crystallographic analysis of subunit F (F1-94), an essential coupling subunit of the eukaryotic V1VO-ATPase from Saccharomyces cerevisiae
由: Basak, Sandip, et al.
出版: (2013)

Diverse reactivity of a tricoordinate organoboron L2PhB: (L = oxazol-2-ylidene) towards alkali metal, group 9 metal, and coinage metal precursors
由: Kong, Lingbing, et al.
出版: (2015)

Synthesis of metal complex crystals of bisisoquenolines derivatives and their x-ray crystallography
由: Teng, Jun Boon.
出版: (2010)

Structure-property relationships in framework materials: anomalous mechanics by design
由: Collings, I, et al.
出版: (2014)

Local structure/property relationships in functional materials
由: Young, CA
出版: (2014)

Crystallographic studies on 2-oxoglutarate dependent oxygenases
由: Aik, WS
出版: (2014)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
由: Marles-Wright, J
出版: (2005)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
由: Marles-Wright, J
出版: (2005)

Structural studies of cell adhesion and division
由: Yates, LA
出版: (2012)

Structure of the RNA-dependent RNA polymerase from influenza C virus
由: Hengrung, N
出版: (2014)

Investigation of X-ray induced radiation damage in proteins, nucleic acids and their complexes
由: Bury, C
出版: (2017)

Protein-protein recognition in biological systems exhibiting highly-conserved tertiary structure: cytochrome P450
由: Johnson, E, et al.
出版: (2013)

Investigating high-affinity non-covalent protein-ligand interaction via variants of streptavidin
由: Chivers, C
出版: (2011)

Effect of annealing temperature on microstructure and UV light photocatalytic activity of TiO2 films grown by atmospheric pressure CVD
由: Soutar, Andrew McIntosh, et al.
出版: (2015)

Structural and mechanistic studies on prolyl hydroxylases
由: Chowdhury, R
出版: (2008)

Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-hydroxymethyl- 5-methyloctahydroindolizine-1,2- diol hydrobromide]
由: Thompson, A, et al.
出版: (2009)

Three dimensional QSAR : applications in pharmacology and toxicology /
由: 505265 Doucet, Jean-Pierre, et al.
出版: (2010)

Pharmacological targeting of Sam68 functions in colorectal cancer stem cells
由: Angelique N. Masibag, et al.
出版: (2021-12-01)

Small molecule colorimetric and fluorescent probes for specific protein detection
由: Egleton, JE
出版: (2015)

Sulfonamide supported catalysts for the ring opening polymerisation of cyclic esters
由: Schwarz, A
出版: (2010)

Structural chemistry of transition metal dicyanometallates
由: Hill, J
出版: (2016)

The crystal chemistry and hydrogen storage properties of light metal borohydrides
由: Culligan, SD
出版: (2013)

Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes
由: Jungin Kwon, et al.
出版: (2023-03-01)

High density ammonia storage materials
由: Royse, D, et al.
出版: (2011)