Chemical probes for bromodomains outside the BET family

Chemical probes for bromodomains outside the BET family

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Príomhchruthaitheoirí:	Brennan, P, Martin, S, Monteiro, O, Fedorov, O, Knapp, S, Hay, D, Wells, C, Filippakopoulos, P, Picaud, S, Muller-Knapp, S, Keates, T, Yapp, C, Philpott, M, Schofield, C, Burgess-Brown, N, Shrestha, L, Strain-Damerell, C
Formáid:	Conference item
Foilsithe / Cruthaithe:	2013

Míreanna comhchosúla

Developing chemical probes for the BET bromodomains
de réir: Hewings, D, et al.
Foilsithe / Cruthaithe: (2012)

The design and synthesis of 5-and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains
de réir: Hay, D, et al.
Foilsithe / Cruthaithe: (2013)

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.
de réir: Picaud, S, et al.
Foilsithe / Cruthaithe: (2013)

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
de réir: Picaud, S, et al.
Foilsithe / Cruthaithe: (2013)

[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains.
de réir: Fedorov, O, et al.
Foilsithe / Cruthaithe: (2014)

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.
de réir: Filippakopoulos, P, et al.
Foilsithe / Cruthaithe: (2012)

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
de réir: Filippakopoulos, P, et al.
Foilsithe / Cruthaithe: (2012)

Selective inhibition of BET bromodomains.
de réir: Filippakopoulos, P, et al.
Foilsithe / Cruthaithe: (2010)

Selective inhibition of BET bromodomains.
de réir: Filippakopoulos, P, et al.
Foilsithe / Cruthaithe: (2010)

Chemical probes and inhibitors of bromodomains outside the BET family
de réir: Moustakim, M, et al.
Foilsithe / Cruthaithe: (2016)

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains
de réir: Hay, D, et al.
Foilsithe / Cruthaithe: (2014)

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.
de réir: Philpott, M, et al.
Foilsithe / Cruthaithe: (2011)

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.
de réir: Philpott, M, et al.
Foilsithe / Cruthaithe: (2011)

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching
de réir: Philpott, M, et al.
Foilsithe / Cruthaithe: (2014)

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.
de réir: Picaud, S, et al.
Foilsithe / Cruthaithe: (2013)

Small-molecule bromodomain inhibitors for cancer therapy
de réir: Qi, J, et al.
Foilsithe / Cruthaithe: (2010)

3,5-Dimethylisoxazoles inhibit the bromodomain-histone protein-protein interaction
de réir: Hewings, D, et al.
Foilsithe / Cruthaithe: (2012)

Promiscuous targeting of bromodomains by Bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia
de réir: Picaud, S, et al.
Foilsithe / Cruthaithe: (2016)

Evaluation of linker length effects on a BET bromodomain probe
de réir: Traquete, R, et al.
Foilsithe / Cruthaithe: (2019)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.
de réir: Hewings, D, et al.
Foilsithe / Cruthaithe: (2011)

The bromodomain interaction module.
de réir: Filippakopoulos, P, et al.
Foilsithe / Cruthaithe: (2012)

The bromodomain interaction module
de réir: Filippakopoulos, P, et al.
Foilsithe / Cruthaithe: (2012)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
de réir: Hewings, D, et al.
Foilsithe / Cruthaithe: (2011)

Developing small molecule inhibitors of the CREBBP bromodomain-histone interaction
de réir: Rooney, T, et al.
Foilsithe / Cruthaithe: (2012)

Discovery of BET bromodomain inhibitors and their role in target validation
de réir: Mueller, S, et al.
Foilsithe / Cruthaithe: (2014)

Bromodomains as therapeutic targets.
de réir: Muller, S, et al.
Foilsithe / Cruthaithe: (2011)

Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding.
de réir: Kempen, H, et al.
Foilsithe / Cruthaithe: (2013)

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
de réir: Jennings, L, et al.
Foilsithe / Cruthaithe: (2018)

Targeting bromodomains: epigenetic readers of lysine acetylation.
de réir: Filippakopoulos, P, et al.
Foilsithe / Cruthaithe: (2014)

Synthesis and biological investigation of (+)-JD1, an organometallic BET bromodomain inhibitor
de réir: Hassell-Hart, S, et al.
Foilsithe / Cruthaithe: (2019)

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.
de réir: Ciceri, P, et al.
Foilsithe / Cruthaithe: (2014)

Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.
de réir: Hewings, D, et al.
Foilsithe / Cruthaithe: (2013)

Corrigendum: Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.
de réir: Ciceri, P, et al.
Foilsithe / Cruthaithe: (2014)

Histone recognition and large-scale structural analysis of the human bromodomain family.
de réir: Filippakopoulos, P, et al.
Foilsithe / Cruthaithe: (2012)

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.
de réir: Fedorov, O, et al.
Foilsithe / Cruthaithe: (2015)

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction
de réir: Rooney, T, et al.
Foilsithe / Cruthaithe: (2014)

Effect of BET missense mutations on bromodomain function, inhibitor binding and stability
de réir: Lori, L, et al.
Foilsithe / Cruthaithe: (2016)

Interactome rewiring following pharmacological targeting of BET bromodomains
de réir: Lambert, J-P, et al.
Foilsithe / Cruthaithe: (2018)

Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.
de réir: Fisher, K, et al.
Foilsithe / Cruthaithe: (2013)

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
de réir: Cribbs, AP, et al.
Foilsithe / Cruthaithe: (2021)