A hallmark of balancing selection is present at the promoter region of interleukin 10.
As an anti-inflammatory mediator IL10 is beneficial in certain contexts and deleterious in others. As increased production of IL10 favours protection against inflammatory disease, whereas low production promotes elimination of foreign pathogens by the host, we investigated the possible influence of...
| প্রধান লেখক: | , , , , , , , |
|---|---|
| বিন্যাস: | Journal article |
| ভাষা: | English |
| প্রকাশিত: |
2006
|
| _version_ | 1826307073425539072 |
|---|---|
| author | Wilson, J Rockett, K Keating, B Jallow, M Pinder, M Sisay-Joof, F Newport, M Kwiatkowski, D |
| author_facet | Wilson, J Rockett, K Keating, B Jallow, M Pinder, M Sisay-Joof, F Newport, M Kwiatkowski, D |
| author_sort | Wilson, J |
| collection | OXFORD |
| description | As an anti-inflammatory mediator IL10 is beneficial in certain contexts and deleterious in others. As increased production of IL10 favours protection against inflammatory disease, whereas low production promotes elimination of foreign pathogens by the host, we investigated the possible influence of balancing selection at this locus. We began by resequencing 48 European and 48 African chromosomes across 2.2 kb of the IL10 promoter region, and compared this with four neighbouring gene regions: MK2, IL19, IL20 and IL24. Analysis of nucleotide diversity showed a positive Tajima's D-test for IL10 in Europeans, of borderline statistical significance (1.89, P=0.05). Analysis of F(st) values showed significant population divergence at MK2, IL19, IL20 and IL24 (P<0.01) but not at IL10. Taken together, these findings are consistent with the hypothesis that balancing selection has played a role in the evolution of polymorphisms in the IL10 promoter region. |
| first_indexed | 2024-03-07T06:57:31Z |
| format | Journal article |
| id | oxford-uuid:fe9f6fc5-b976-46a5-9fdc-383fa00b900a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:57:31Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:fe9f6fc5-b976-46a5-9fdc-383fa00b900a2022-03-27T13:38:13ZA hallmark of balancing selection is present at the promoter region of interleukin 10.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fe9f6fc5-b976-46a5-9fdc-383fa00b900aEnglishSymplectic Elements at Oxford2006Wilson, JRockett, KKeating, BJallow, MPinder, MSisay-Joof, FNewport, MKwiatkowski, DAs an anti-inflammatory mediator IL10 is beneficial in certain contexts and deleterious in others. As increased production of IL10 favours protection against inflammatory disease, whereas low production promotes elimination of foreign pathogens by the host, we investigated the possible influence of balancing selection at this locus. We began by resequencing 48 European and 48 African chromosomes across 2.2 kb of the IL10 promoter region, and compared this with four neighbouring gene regions: MK2, IL19, IL20 and IL24. Analysis of nucleotide diversity showed a positive Tajima's D-test for IL10 in Europeans, of borderline statistical significance (1.89, P=0.05). Analysis of F(st) values showed significant population divergence at MK2, IL19, IL20 and IL24 (P<0.01) but not at IL10. Taken together, these findings are consistent with the hypothesis that balancing selection has played a role in the evolution of polymorphisms in the IL10 promoter region. |
| spellingShingle | Wilson, J Rockett, K Keating, B Jallow, M Pinder, M Sisay-Joof, F Newport, M Kwiatkowski, D A hallmark of balancing selection is present at the promoter region of interleukin 10. |
| title | A hallmark of balancing selection is present at the promoter region of interleukin 10. |
| title_full | A hallmark of balancing selection is present at the promoter region of interleukin 10. |
| title_fullStr | A hallmark of balancing selection is present at the promoter region of interleukin 10. |
| title_full_unstemmed | A hallmark of balancing selection is present at the promoter region of interleukin 10. |
| title_short | A hallmark of balancing selection is present at the promoter region of interleukin 10. |
| title_sort | hallmark of balancing selection is present at the promoter region of interleukin 10 |
| work_keys_str_mv | AT wilsonj ahallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT rockettk ahallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT keatingb ahallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT jallowm ahallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT pinderm ahallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT sisayjooff ahallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT newportm ahallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT kwiatkowskid ahallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT wilsonj hallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT rockettk hallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT keatingb hallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT jallowm hallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT pinderm hallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT sisayjooff hallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT newportm hallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 AT kwiatkowskid hallmarkofbalancingselectionispresentatthepromoterregionofinterleukin10 |