Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain.

Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain.

The Forkhead transcription factor FoxM1 is an important regulator of gene expression during the G(2) phase. Here, we show that FoxM1 transcriptional activity is kept low during G(1)/S through the action of its N-terminal autoinhibitory domain. We found that cyclin A/cdk complexes are required to pho...

书目详细资料
Main Authors:	Laoukili, J, Alvarez, M, Meijer, L, Stahl, M, Mohammed, S, Kleij, L, Heck, A, Medema, R
格式:	Journal article
语言:	English
出版:	2008

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