The new immunosuppression: intervention at the dendritic cell-T-cell interface.
Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a 'tolerogenic context'. This would have obvious benefit in minimising the nee...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1826307080846311424 |
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| author | Paterson, A Yates, S Nolan, K Waldmann, H |
| author_facet | Paterson, A Yates, S Nolan, K Waldmann, H |
| author_sort | Paterson, A |
| collection | OXFORD |
| description | Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a 'tolerogenic context'. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function. |
| first_indexed | 2024-03-07T06:57:37Z |
| format | Journal article |
| id | oxford-uuid:feaa67c8-2ef3-4d4c-bf11-5a7c7918e92f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:57:37Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:feaa67c8-2ef3-4d4c-bf11-5a7c7918e92f2022-03-27T13:38:21ZThe new immunosuppression: intervention at the dendritic cell-T-cell interface.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:feaa67c8-2ef3-4d4c-bf11-5a7c7918e92fEnglishSymplectic Elements at Oxford2005Paterson, AYates, SNolan, KWaldmann, HDendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a 'tolerogenic context'. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function. |
| spellingShingle | Paterson, A Yates, S Nolan, K Waldmann, H The new immunosuppression: intervention at the dendritic cell-T-cell interface. |
| title | The new immunosuppression: intervention at the dendritic cell-T-cell interface. |
| title_full | The new immunosuppression: intervention at the dendritic cell-T-cell interface. |
| title_fullStr | The new immunosuppression: intervention at the dendritic cell-T-cell interface. |
| title_full_unstemmed | The new immunosuppression: intervention at the dendritic cell-T-cell interface. |
| title_short | The new immunosuppression: intervention at the dendritic cell-T-cell interface. |
| title_sort | new immunosuppression intervention at the dendritic cell t cell interface |
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