Investigating DNA replication perturbance induced by CRISPR-Cas9 variants
Single-Stranded DNA breaks (SSBs) represent one of the most abundant DNA lesions occurring in the cells of living organisms. If encountered by the DNA replication machinery, SSBs can be converted into double-stranded DNA breaks (DSBs). Homologous recombination (HR) pathways are deployed to repair th...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
2023
|
| Subjects: |