Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets.
In the ferret, 5-HT3 receptor antagonists are effective in controlling emesis produced by cytotoxic agents or radiation. To investigate the possibility that substance P has a role, as well as 5-HT, in the emetic reflex pathway, we have examined the anti-emetic effects of a NK1 receptor antagonist (r...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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| _version_ | 1826307096697634816 |
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| author | Bountra, C Bunce, K Dale, T Gardner, C Jordan, C Twissell, D Ward, P |
| author_facet | Bountra, C Bunce, K Dale, T Gardner, C Jordan, C Twissell, D Ward, P |
| author_sort | Bountra, C |
| collection | OXFORD |
| description | In the ferret, 5-HT3 receptor antagonists are effective in controlling emesis produced by cytotoxic agents or radiation. To investigate the possibility that substance P has a role, as well as 5-HT, in the emetic reflex pathway, we have examined the anti-emetic effects of a NK1 receptor antagonist (racemic CP-99,994) in the ferret. Racemic CP-99,994 was effective against a range of emetogens, comprising cytotoxic drugs, radiation, morphine, ipecacuanha and copper sulphate. |
| first_indexed | 2024-03-07T06:57:51Z |
| format | Journal article |
| id | oxford-uuid:febde167-7fd1-4273-ad28-2c9cd7a05b2e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:57:51Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:febde167-7fd1-4273-ad28-2c9cd7a05b2e2022-03-27T13:39:03ZAnti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:febde167-7fd1-4273-ad28-2c9cd7a05b2eEnglishSymplectic Elements at Oxford1993Bountra, CBunce, KDale, TGardner, CJordan, CTwissell, DWard, PIn the ferret, 5-HT3 receptor antagonists are effective in controlling emesis produced by cytotoxic agents or radiation. To investigate the possibility that substance P has a role, as well as 5-HT, in the emetic reflex pathway, we have examined the anti-emetic effects of a NK1 receptor antagonist (racemic CP-99,994) in the ferret. Racemic CP-99,994 was effective against a range of emetogens, comprising cytotoxic drugs, radiation, morphine, ipecacuanha and copper sulphate. |
| spellingShingle | Bountra, C Bunce, K Dale, T Gardner, C Jordan, C Twissell, D Ward, P Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets. |
| title | Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets. |
| title_full | Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets. |
| title_fullStr | Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets. |
| title_full_unstemmed | Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets. |
| title_short | Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets. |
| title_sort | anti emetic profile of a non peptide neurokinin nk1 receptor antagonist cp 99 994 in ferrets |
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