Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis

Uveitis is characterised by breakdown of the blood-retinal barrier (BRB), allowing infiltration of immune cells that mediate intraocular inflammation, which can lead to irreversible damage of the neuroretina and the loss of sight. Treatment of uveitis relies heavily on corticosteroids and systemic i...

Полное описание

Библиографические подробности
Главные авторы: Quinn, J, Salman, A, Paluch, C, Jackson-Wood, M, McClements, ME, Luo, J, Davis, SJ, Cornall, RJ, MacLaren, RE, Dendrou, CA, Xue, K
Формат: Journal article
Язык:English
Опубликовано: Nature Research 2024