The protective role of DOT1L in UV-induced melanomagenesis

The protective role of DOT1L in UV-induced melanomagenesis

The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis. Here, we demonstrate that, in contrast to MLL-rearranged leukemia, DOT1L plays a protective role in ultraviolet radiation (UVR)-induced melanoma development. Specifically, the DOT1L gen...

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Những tác giả chính:	Zhu, B, Chen, S, Wang, H, Yin, C, Han, C, Peng, C, Liu, Z, Wan, L, Zhang, X, Zhang, J, Lian, C, Ma, P, Xu, Z, Prince, S, Wang, T, Gao, X, Shi, Y, Liu, D, Liu, M, Wei, W, Wei, Z, Pan, J, Wang, Y, Xuan, Z, Hess, J, Hayward, N, Goding, C, Chen, X, Zhou, J, Cui, R
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Springer Nature 2018

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