The protective role of DOT1L in UV-induced melanomagenesis

The protective role of DOT1L in UV-induced melanomagenesis

The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis. Here, we demonstrate that, in contrast to MLL-rearranged leukemia, DOT1L plays a protective role in ultraviolet radiation (UVR)-induced melanoma development. Specifically, the DOT1L gen...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Zhu, B, Chen, S, Wang, H, Yin, C, Han, C, Peng, C, Liu, Z, Wan, L, Zhang, X, Zhang, J, Lian, C, Ma, P, Xu, Z, Prince, S, Wang, T, Gao, X, Shi, Y, Liu, D, Liu, M, Wei, W, Wei, Z, Pan, J, Wang, Y, Xuan, Z, Hess, J, Hayward, N, Goding, C, Chen, X, Zhou, J, Cui, R
Materialtyp:	Journal article
Språk:	English
Publicerad:	Springer Nature 2018

Liknande verk

The protective role of DOT1L in UV-induced melanomagenesis
av: Bo Zhu, et al.
Publicerad: (2018-01-01)

Palmitoylation-dependent activation of MC1R prevents melanomagenesis
av: Chen, S, et al.
Publicerad: (2017)

AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis
av: Sun, Y, et al.
Publicerad: (2023)

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
av: Chen, S, et al.
Publicerad: (2019)

Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis
av: Yin, C, et al.
Publicerad: (2019)

Deregulation of cell growth and apoptosis in UV-induced melanomagenesis
av: Allal Ouhtit, et al.
Publicerad: (2020-03-01)

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
av: Shuyang Chen, et al.
Publicerad: (2019-02-01)

Review: The Key Factors to Melanomagenesis
av: Cristina-Raluca (Jitian) Mihulecea, et al.
Publicerad: (2023-01-01)

Entangled states of two quantum dots mediated by Majorana fermions
av: Z C Shi, et al.
Publicerad: (2016-01-01)

Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
av: Shujing Liu, et al.
Publicerad: (2018-12-01)

Opportunistic Detection for Pancreatic Cystic Lesions During Chest Multidetector CT Scans for Lung Cancer Screening
av: Chen X, et al.
Publicerad: (2021-10-01)

Ultraviolet Radiation and Melanomagenesis: From Mechanism to Immunotherapy
av: Xiaoying Sun, et al.
Publicerad: (2020-07-01)

Glacial lake inventory of high-mountain Asia in 1990 and 2018 derived from Landsat images
av: X. Wang, et al.
Publicerad: (2020-09-01)

Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction
av: Li T, et al.
Publicerad: (2025-02-01)

Photovoltaic field effect transistor (PVFET)-based Ge/Si photodetector for low-power silicon photonics
av: Q. Y. Zeng, et al.
Publicerad: (2019-08-01)

In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin
av: Wang, Hequn, et al.
Publicerad: (2017)

LncRNA GATA6-AS1 Inhibits the Progression of Non-Small Cell Lung Cancer via Repressing microRNA-543 to Up-Regulating RKIP [Expression of Concern]
av: Gong Z, et al.
Publicerad: (2021-11-01)

LncRNA GATA6-AS1 Inhibits the Progression of Non-Small Cell Lung Cancer via Repressing microRNA-543 to Up-Regulating RKIP
av: Gong Z, et al.
Publicerad: (2020-09-01)

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis
av: Giuseppina Claps, et al.
Publicerad: (2016-05-01)

Author Correction: Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
av: Shujing Liu, et al.
Publicerad: (2019-03-01)

NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis
av: Wan Z, et al.
Publicerad: (2019-09-01)

Polypropylene/Mg3Al-tartrazine LDH nanocomposites with enhanced thermal stability, UV absorption, and rheological properties
av: Wang, Q, et al.
Publicerad: (2013)

Ergothioneine Protects Against UV-Induced Oxidative Stress Through the PI3K/AKT/Nrf2 Signaling Pathway
av: Li Y, et al.
Publicerad: (2024-06-01)

Elucidation of novel regulatory pathways in melanogenesis and melanomagenesis
av: Berns, HM
Publicerad: (2024)

Evaluating the response of <i>δ</i><sup>13</sup>C in <i>Haloxylon ammodendron</i>, a dominant C<sub>4</sub> species in Asian desert ecosystems, to water and nitrogen addition as well as the availability of its <i>δ</i><sup>13</sup>C as an indicator of water use efficiency
av: Z. Chen, et al.
Publicerad: (2021-05-01)

Fatigue performance of beta titanium alloy topological porous structures fabricated by laser powder bed fusion
av: Z.Y. Wu, et al.
Publicerad: (2024-03-01)

The two-way feedback mechanism between unfavorable meteorological conditions and cumulative aerosol pollution in various haze regions of China
av: J. Zhong, et al.
Publicerad: (2019-03-01)

Antimicrobial and Remineralization of Carboxymethyl Chitosan and Xylitol Functionalized Carbon Dots Coating on Orthodontic Brackets
av: Liu J, et al.
Publicerad: (2024-12-01)

The Ross Sea and Amundsen Sea Ice–Sea Model (RAISE v1.0): a high-resolution ocean–sea ice–ice shelf coupling model for simulating the Dense Shelf Water and Antarctic Bottom Water in the Ross Sea, Antarctica
av: Z. Zhang, et al.
Publicerad: (2025-03-01)

Measurement report: Dust and anthropogenic aerosols' vertical distributions over northern China dense aerosols gathered at the top of the mixing layer
av: Z. Wang, et al.
Publicerad: (2023-11-01)

The jigsaw puzzle of pedigree: whole-genome resequencing reveals genetic diversity and ancestral lineage in Sunong black pigs
av: X.W. Ye, et al.
Publicerad: (2023-11-01)

Carbon Quantum Dots: In vitro and in vivo Studies on Biocompatibility and Biointeractions for Optical Imaging
av: Tian X, et al.
Publicerad: (2020-08-01)

Multiple molecular pathways in melanomagenesis: characterization of therapeutic targets
av: Giuseppe ePalmieri, et al.
Publicerad: (2015-08-01)

The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus
av: Tan C, et al.
Publicerad: (2021-01-01)

Carbon Quantum Dots: In vitro and in vivo Studies on Biocompatibility and Biointeractions for Optical Imaging [Corrigendum]
av: Tian X, et al.
Publicerad: (2022-06-01)

MC1R is a potent regulator of PTEN after UV exposure in melanocytes.
av: Cao, J, et al.
Publicerad: (2013)

Quantifying the Effect of Xiluodu Reservoir on the Temperature of the Surrounding Mountains
av: D.C. Wang, et al.
Publicerad: (2020-05-01)

Usefulness of serum D-dimer for preoperative diagnosis of infected nonunion after open reduction and internal fixation
av: Wang Z, et al.
Publicerad: (2019-07-01)

Effects of feeding corn bran and soybean hulls on nutrient digestibility, rumen microbial protein synthesis, and growth performance of finishing lambs
av: X.Y. Hao, et al.
Publicerad: (2021-03-01)

Distribution and air-sea exchange of mercury (Hg) in the Yellow Sea
av: Z. J. Ci, et al.
Publicerad: (2011-03-01)