An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides

An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides

Oligonucleotides that target mRNA have great promise as therapeutic agents for life-threatening conditions but suffer from poor bioavailability, hence high cost. As currently untreatable diseases come within the reach of oligonucleotide therapies, new analogues are urgently needed to address this. W...

书目详细资料
Main Authors:	Baker, YR, Thorpe, C, Chen, J, Poller, LM, Cox, L, Kumar, P, Lim, WF, Lie, L, McClorey, G, Epple, S, Singleton, D, McDonough, MA, Hardwick, JS, Christensen, KE, Wood, MJA, Hall, JP, El-Sagheer, AH, Brown, T
格式:	Journal article
语言:	English
出版:	Springer Nature 2022

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