Enriched enrollment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review.

AIMS: Enriched enrollment study designs have been suggested to be useful for proof of concept when only a proportion of the diseased population responds to a treatment intervention. We aim to investigate whether this really is the case in trials of pregabalin and gabapentin in neuropathic pain. MET...

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Hlavní autoři: Straube, S, Derry, S, McQuay, H, Moore, R
Médium: Journal article
Jazyk:English
Vydáno: 2008