Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography
Electrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2024
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| _version_ | 1811140402783191040 |
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| author | Coles, L Ventrella, D Carnicer-Lombarte, A Elmi, A Troughton, JG Mariello, M El Hadwe, S Woodington, BJ Bacci, ML Malliaras, GG Barone, DG Proctor, CM |
| author_facet | Coles, L Ventrella, D Carnicer-Lombarte, A Elmi, A Troughton, JG Mariello, M El Hadwe, S Woodington, BJ Bacci, ML Malliaras, GG Barone, DG Proctor, CM |
| author_sort | Coles, L |
| collection | OXFORD |
| description | Electrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators. We show that the 32-electrode device can be packaged using origami-inspired folding into a compressed state and implanted through a small burr-hole craniotomy, then expanded on the surface of the brain for large-area cortical coverage. The implantation, expansion, and recording functionality of the device is confirmed in-vitro and in porcine in-vivo models. The integration of shape actuation into neural implants provides a clinically viable pathway to realize large-area neural interfaces via minimally invasive surgical techniques. |
| first_indexed | 2024-09-25T04:21:25Z |
| format | Journal article |
| id | oxford-uuid:ff0d5321-0e19-4114-a2ae-55f6976ac1c0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:21:25Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:ff0d5321-0e19-4114-a2ae-55f6976ac1c02024-08-05T19:33:57ZOrigami-inspired soft fluidic actuation for minimally invasive large-area electrocorticographyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ff0d5321-0e19-4114-a2ae-55f6976ac1c0EnglishJisc Publications RouterNature Research2024Coles, LVentrella, DCarnicer-Lombarte, AElmi, ATroughton, JGMariello, MEl Hadwe, SWoodington, BJBacci, MLMalliaras, GGBarone, DGProctor, CMElectrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators. We show that the 32-electrode device can be packaged using origami-inspired folding into a compressed state and implanted through a small burr-hole craniotomy, then expanded on the surface of the brain for large-area cortical coverage. The implantation, expansion, and recording functionality of the device is confirmed in-vitro and in porcine in-vivo models. The integration of shape actuation into neural implants provides a clinically viable pathway to realize large-area neural interfaces via minimally invasive surgical techniques. |
| spellingShingle | Coles, L Ventrella, D Carnicer-Lombarte, A Elmi, A Troughton, JG Mariello, M El Hadwe, S Woodington, BJ Bacci, ML Malliaras, GG Barone, DG Proctor, CM Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography |
| title | Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography |
| title_full | Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography |
| title_fullStr | Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography |
| title_full_unstemmed | Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography |
| title_short | Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography |
| title_sort | origami inspired soft fluidic actuation for minimally invasive large area electrocorticography |
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