Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy.

Broad TCR usage in functional HIV-1-specific CD8+ T cell expansions driven by vaccination during highly active antiretroviral therapy.

During chronic HIV-1 infection, continuing viral replication is associated with impaired proliferative capacity of virus-specific CD8+ T cells and with the expansion and persistence of oligoclonal T cell populations. TCR usage may significantly influence CD8+ T cell-mediated control of AIDS viruses;...

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Bibliographic Details
Main Authors:	Yang, H, Dong, T, Turnbull, E, Ranasinghe, S, Ondondo, B, Goonetilleke, N, Winstone, N, di Gleria, K, Bowness, P, Conlon, C, Borrow, P, Hanke, T, McMichael, A, Dorrell, L
Format:	Journal article
Language:	English
Published:	2007

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