Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthritis (RA) treatment. However, a considerable proportion of RA patients are refractory to LEF...

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Bibliographic Details
Main Authors:	Peres, RS, Santos, GB, Cecilio, NT, Jabor, VAP, Niehues, M, Torres, BGS, Buqui, G, Silva, CHTP, Costa, TD, Lopes, NP, Nonato, MC, Ramalho, FS, Louzada-Júnior, P, Cunha, TM, Cunha, FQ, Emery, FS, Alves-Filho, JC
Format:	Journal article
Language:	English
Published:	BioMed Central 2017

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